SOX4

Gene Information

Official Symbol: SOX4
Official Name: SRY-box transcription factor 4
Aliases and Previous Symbols: N/A
Entrez ID: 6659
UniProt: Q06945
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008].
UniProt Summary: Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-4.49
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-3.64
Oligomycin-A 2μM R00 exp25	-3.55
Nicotine 3000μM R08 exp510	-3.43
Milciclib 2μM R08 exp502	-3
Vemurafenib 6.6μM R02 exp89	-2.98
WYE-354 6μM R02 exp90	-2.68
Colchicine 0.009μM R05 exp215	-2.67
BVD-523 15μM R02 exp67	-2.65
Bisphenol A 100μM R06 exp269	-2.61
Nutlin-3A 1.6μM R06 exp294	-2.53
Azithromycin 100μM R08 exp452	-2.52
CB-5083 0.4μM R08 exp468	-2.51
Lead acetate 2000μM R08 exp498 no dilution day6	-2.48
KU-0063794 3.8μM R02 exp71	-2.4
Staurosporine 0.02μM R08 exp524	-2.3
CB-839 10μM R05 exp224	-2.28
Radicicol 0.16μM R05 exp242	-2.26
PU-H71 1μM R08 exp515	-2.25
S-trityl-L-cysteine 0.5μM R05 exp243	-2.23
Nocodazole 0.2μM R00 exp24	-2.21
UM0129480 7μM R02 exp85	-2.15
Ethanol 0.01 R05 exp234	-2.12
BML-284 0.09μM R08 exp460	-2.04
iCRT14 30μM R08 exp492	-2.04
Taxol 0.004μM R03 exp103	-2.04
LLY-283 2.6μM R06 exp290	-2.03
Fluvastatin 2.2μM R06 exp282	-1.99
Etoposide 0.1μM R05 exp198	-1.95
Quinacrine 2.5μM R03 exp146	-1.89
UNC1999 2μM R03 exp155	-1.88
5-Fluorouracil 2μM R00 exp1	-1.85
BI-6727 0.0125μM R03 exp97	-1.84
Epothilone-B 0.0015μM R05 exp231	-1.84
Alda-1 10μM R06 exp262	-1.82
Demecolcine 0.03μM R05 exp228	-1.82
Momordin-Ic 10μM R08 exp506	-1.82
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.82
All-trans-Retinoic-Acid 40μM R07 exp334	-1.81
MS023 2μM R03 exp134	-1.78
Cannabidiol 20μM R08 exp466	-1.75
TIC10 10μM R08 exp532	-1.74
Genistein 15μM R07 exp360	-1.73
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.72
Thapsigargin 0.005μM R07 exp407	-1.72
UM131593 0.2μM R03 exp106	-1.71
PNU96415E 10μM R03 exp145	1.72
YM155 0.0002μM R01 exp61	1.78
Quercetin 20μM R08 exp517	1.85
Nifuroxazide 1μM R01 exp51	1.87
Dynasore 10μM R04 exp180	1.9
Arsenate 40μM R06 exp264	2.02
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.06
LY2090314 0.003μM R08 exp499	2.07
Cytochalasin-B 5μM R07 exp349	2.11
CCCP 1μM R00 exp11	2.18
Rotenone 20μM R00 exp34	2.27
Olaparib 4μM R08 exp512	3.1
Trimetrexate 0.03μM R08 exp535	3.24
THZ531 0.11μM R07 exp409	3.45
THZ531 0.225μM R08 exp444	3.55
THZ531 0.11 to 0.125μM on day4 R07 exp410	4.18
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	4.73
THZ531 0.11 to 0.175μM on day4 R07 exp413	4.76

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 19001
Expression level (log2 read counts): 7.68

Expression Distribution

positive regulation of N-terminal peptidyl-lysine acetylation
regulation of N-terminal peptidyl-lysine acetylation
pro-B cell differentiation
ascending aorta morphogenesis
atrial septum primum morphogenesis
ascending aorta development
septum primum development
noradrenergic neuron differentiation
cardiac ventricle formation
mitral valve morphogenesis
cardiac chamber formation
limb bud formation
mitral valve development
lymphoid progenitor cell differentiation
glial cell proliferation
atrial septum morphogenesis
cardiac right ventricle morphogenesis
sympathetic nervous system development
atrial septum development
nuclear transcription factor complex
atrioventricular valve morphogenesis
positive regulation of protein maturation
atrioventricular valve development
aorta morphogenesis
cardiac atrium morphogenesis
positive regulation of peptidyl-lysine acetylation
spinal cord motor neuron differentiation
cardiac atrium development
endocrine pancreas development
DNA damage response, detection of DNA damage
positive regulation of protein acetylation
ventricular septum morphogenesis
neuroepithelial cell differentiation
autonomic nervous system development
ventral spinal cord development
aorta development
heart valve morphogenesis
cell differentiation in spinal cord
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
signal transduction involved in mitotic DNA damage checkpoint