MLX

Entrez Summary: The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Campthothecin 0.001μM R06 exp270	-1.78
SNS-032 15μM R08 exp443	-1.74
CAY10603 0.55μM R08 exp467	-1.7
BI-2536 0.0042μM R03 exp95	1.73
CoCl2 18μM R07 exp346	1.83
UM0129480 7μM R02 exp85	1.93
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.05
Ethanol 0.01 R05 exp234	2.11
Betulinic acid 10 to 15μM on day4 R05 exp222	2.82
Oligomycin-A 2μM R00 exp25	3.27
AICAR 240μM R05 exp211	3.49
iCRT14 30μM R08 exp492	3.65
2-Deoxy-D-glucose 800μM R05 exp214	8.49

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
TXNIP	0.736
MLXIP	0.664

nuclear membrane
DNA-binding transcription repressor activity, RNA polymerase II-specific
RNA polymerase II regulatory region sequence-specific DNA binding
transcription factor binding
protein heterodimerization activity
DNA-binding transcription factor activity
negative regulation of transcription by RNA polymerase II
protein homodimerization activity
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
negative regulation of gene expression
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process