SP2 [The Human Chemical-Genetic Interaction Map Project]

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======= SP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SP2
  * **<color #00a2e8>Official Name</color>**: Sp2 transcription factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6668|6668]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02086|Q02086]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601801|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|multicellular organism growth|
|histone deacetylase binding|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|developmental growth|
|growth|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of gene expression|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.71|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.19|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.16|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.88|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.83|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.74|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.78|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.82|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.9|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.91|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.94|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.18|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.28|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.39|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.61|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|3.03|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|3.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5859
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SP2 Expression in NALM6 Cells: 4.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>