BBX

Entrez Summary: N/A
UniProt Summary: Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Erlotinib 10μM R05 exp216	1.73
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.74
Vinblastine 0.015μM R05 exp208	1.74
Rapamycin 2μM R07 exp306	1.75
Citral 75μM R06 exp275	1.81
TRAIL 50ng/ml R00 exp36	1.82
ML-792 0.2μM R08 exp505	1.86
Ethanol 0.01 R05 exp234	1.88
TRAIL 5ng/ml R00 exp35	1.88
Dimethyl-Sulfoxide 1pc R03 exp120	1.96
Lead acetate 2000μM R08 exp498 no dilution day6	2.07
Lead acetate 2000μM R08 exp497	2.08
Oligomycin-A 2μM R00 exp25	2.1
THZ531 0.225μM R08 exp444	2.15
I-BRD9 4μM R07 exp365	2.32
All-trans-Retinoic-Acid 40μM R07 exp334	2.55

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

HMG box
DUF2028

bone development
skeletal system development
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific