BBX [The Human Chemical-Genetic Interaction Map Project]

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======= BBX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BBX
  * **<color #00a2e8>Official Name</color>**: BBX high mobility group box domain containing
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56987|56987]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WY36|Q8WY36]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BBX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BBX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621127|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HMG box|
|DUF2028|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|bone development|
|skeletal system development|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.73|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.74|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.74|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.75|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.81|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.82|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.86|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.88|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.88|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.96|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.07|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.08|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.1|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.15|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.32|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16524
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BBX Expression in NALM6 Cells: 6.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>