TTC14

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.43
Dorsomorphin 5μM R07 exp357	-2.25
42°C R08 exp539	-2.14
THZ531 0.225μM R08 exp444	-1.97
Dimethyl-Sulfoxide 1pc R03 exp120	1.7
UM0131023 0.05μM R05 exp248	1.7
UM0125461 0.74μM R02 exp84	1.72
AICAR 240μM R03 exp116	1.73
5-Fluorouracil 2μM R00 exp1	1.76
Lapatinib 5μM R01 exp47	1.76
Diepoxybutane 3μM R07 exp354	1.79
Rifampicin 10μM R00 exp32	1.86
CB-5083 0.4μM R08 exp468	1.89
Bafilomycin-A1 0.009μM R08 exp454	1.9
S-trityl-L-cysteine 0.5μM R05 exp243	1.93
Erlotinib 10μM R05 exp216	1.99
Bortezomib 0.005μM R00 exp6	2.09
Vemurafenib 6.6μM R02 exp89	2.09
ABT-702 5μM plus CoCl2 18μM R07 exp320	2.1
CoCl2 18μM R07 exp346	2.12
Thapsigargin 0.005μM R07 exp407	2.38
Fluvastatin 2.2μM R06 exp282	2.39
Tubacin 1.6μM R07 exp416	2.42
GSK626616 14μM R08 exp485	2.7
Actinomycin-D 0.001μM R00 exp3	2.72
TRAIL 5ng/ml R00 exp35	2.95
All-trans-Retinoic-Acid 40μM R07 exp334	3.49
I-BRD9 4μM R07 exp365	5.82
BI-D1870 3.15μM R02 exp66	6.05

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution