TTC14 [The Human Chemical-Genetic Interaction Map Project]

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======= TTC14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TTC14
  * **<color #00a2e8>Official Name</color>**: tetratricopeptide repeat domain 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=151613|151613]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96N46|Q96N46]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TTC14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TTC14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleic acid binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.43|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.25|
|[[:results:exp539|42°C R08 exp539]]|-2.14|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.97|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.7|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.7|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.72|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.73|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.76|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.76|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.79|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.86|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.89|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.9|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.93|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.99|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.09|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.09|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.1|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.12|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.38|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.39|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.42|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.7|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.72|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.95|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|3.49|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|5.82|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|6.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fam58a|FAM58A]]|0.721|
|[[:human genes:c:cdk10|CDK10]]|0.643|
|[[:human genes:c:ccnk|CCNK]]|0.532|
|[[:human genes:r:rprd1b|RPRD1B]]|0.53|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 876
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TTC14 Expression in NALM6 Cells: 6.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>