RPL23
Gene Information
- Official Symbol: RPL23
- Official Name: ribosomal protein L23
- Aliases and Previous Symbols: N/A
- Entrez ID: 9349
- UniProt: P62829
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ribosomal L14 |
GO Terms
| cellular response to actinomycin D |
| ribosomal protein import into nucleus |
| response to actinomycin D |
| ubiquitin ligase inhibitor activity |
| large ribosomal subunit rRNA binding |
| negative regulation of ubiquitin protein ligase activity |
| negative regulation of ubiquitin-protein transferase activity |
| transcription coactivator binding |
| protein-DNA complex disassembly |
| regulation of ubiquitin protein ligase activity |
| positive regulation of signal transduction by p53 class mediator |
| negative regulation of cell cycle arrest |
| ribosome |
| negative regulation of ubiquitin-dependent protein catabolic process |
| regulation of ubiquitin-protein transferase activity |
| cytosolic large ribosomal subunit |
| negative regulation of proteolysis involved in cellular protein catabolic process |
| negative regulation of protein ubiquitination |
| positive regulation of cell cycle arrest |
| negative regulation of protein modification by small protein conjugation or removal |
| negative regulation of cellular protein catabolic process |
| protein import into nucleus |
| SRP-dependent cotranslational protein targeting to membrane |
| cotranslational protein targeting to membrane |
| regulation of cell cycle arrest |
| protein targeting to ER |
| establishment of protein localization to endoplasmic reticulum |
| import into nucleus |
| viral transcription |
| cellular response to antibiotic |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| viral gene expression |
| negative regulation of protein catabolic process |
| protein localization to endoplasmic reticulum |
| protein import |
| translational initiation |
| regulation of ubiquitin-dependent protein catabolic process |
| protein targeting to membrane |
| protein localization to nucleus |
| structural constituent of ribosome |
| protein stabilization |
| regulation of signal transduction by p53 class mediator |
| nuclear-transcribed mRNA catabolic process |
| regulation of protein ubiquitination |
| mRNA catabolic process |
| regulation of proteolysis involved in cellular protein catabolic process |
| regulation of protein modification by small protein conjugation or removal |
| protein-containing complex disassembly |
| protein-DNA complex subunit organization |
| RNA catabolic process |
| regulation of cellular protein catabolic process |
| postsynaptic density |
| negative regulation of cellular catabolic process |
| nucleocytoplasmic transport |
| establishment of protein localization to membrane |
| nuclear transport |
| negative regulation of transferase activity |
| positive regulation of cell cycle process |
| regulation of protein stability |
| ubiquitin protein ligase binding |
| response to antibiotic |
| negative regulation of catabolic process |
| negative regulation of cell cycle process |
| cellular response to peptide |
| negative regulation of proteolysis |
| protein targeting |
| nucleobase-containing compound catabolic process |
| positive regulation of cell cycle |
| translation |
| regulation of protein catabolic process |
| cellular component disassembly |
| peptide biosynthetic process |
| focal adhesion |
| establishment of protein localization to organelle |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| response to peptide |
| organic cyclic compound catabolic process |
| protein localization to membrane |
| amide biosynthetic process |
| peptide metabolic process |
| negative regulation of cell cycle |
| negative regulation of protein modification process |
| protein-containing complex |
| cellular response to organonitrogen compound |
| cellular response to nitrogen compound |
| mRNA metabolic process |
| viral process |
| regulation of proteolysis |
| protein localization to organelle |
| regulation of cell cycle process |
| symbiotic process |
| cellular amide metabolic process |
| negative regulation of catalytic activity |
| interspecies interaction between organisms |
| regulation of cellular catabolic process |
| nucleolus |
| negative regulation of transcription by RNA polymerase II |
| cellular macromolecule catabolic process |
| positive regulation of cell population proliferation |
| regulation of transferase activity |
| regulation of catabolic process |
| intracellular protein transport |
| response to organonitrogen compound |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| organonitrogen compound biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| protein transport |
| negative regulation of cellular biosynthetic process |
| intracellular transport |
| peptide transport |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of cell population proliferation |
| cellular nitrogen compound biosynthetic process |
| positive regulation of signal transduction |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| positive regulation of gene expression |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 739/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 26/26 |
| breast | 33/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 351
- Expression level (log2 read counts): 9.01
Expression Distribution
RPL23 Expression in NALM6 Cells: 9.01
