ZBTB18

Gene Information

Official Symbol: ZBTB18
Official Name: zinc finger and BTB domain containing 18
Aliases and Previous Symbols: N/A
Entrez ID: 10472
UniProt: Q99592
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].
UniProt Summary: Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'- [AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus. {ECO:0000269|PubMed:9756912}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM131593 0.2μM R03 exp106	-1.85
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.72
MK2206 4μM R08 exp504	1.74
Rapamycin 0.001μM R08 exp429	1.8
Chloramphenicol 2μM R00 exp12	1.83
A-366 10μM R03 exp115	1.88
HMS-I2 10μM R06 exp288	1.9
Arsenate 40μM R06 exp264	1.91
I-BRD9 4μM R07 exp365	1.92
Rapamycin 1μM R00 exp29	1.96
Thimerosal 0.85μM R08 exp529	1.97
AICAR 240μM R03 exp116	2.11
Hippuristanol 0.12μM R08 exp488	2.11
ZLN024 50μM R08 exp538	2.19
Citral 75μM R06 exp275	2.25
Trimetrexate 0.03μM R08 exp535	2.43
Amiloride 100μM R08 exp447	2.54
iCRT14 30μM R08 exp492	2.55
Myriocin 25μM R06 exp293	2.58
Cannabidiol 20μM R08 exp466	2.92
JQ1 0.8μM R08 exp435	2.92
Rapamycin 10μM R00 exp30	2.96

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10328
Expression level (log2 read counts): 6.32

Expression Distribution

Gene	Correlation
RBM38	0.493
ANP32A	0.46
KDM6A	0.423
ITPK1	0.413
ITPR1	0.413
MEMO1	0.401

nuclear chromosome
skeletal muscle tissue development
skeletal muscle organ development
transcription coactivator activity
striated muscle tissue development
muscle organ development
muscle tissue development
sequence-specific DNA binding
muscle structure development
DNA-binding transcription factor activity
cellular response to DNA damage stimulus
negative regulation of transcription by RNA polymerase II
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
cellular response to stress
negative regulation of gene expression
positive regulation of RNA metabolic process
tissue development
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process