ITPR1

Entrez Summary: This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009].
UniProt Summary: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). {ECO:0000250|UniProtKB:P11881, ECO:0000269|PubMed:27108797}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Torin1 0.08μM R02 exp82	1.71
Nicotinamide 2000μM R01 exp50	1.73
KU-0063794 3.8μM R02 exp71	1.76
Amiloride 100μM R08 exp447	1.89
Golgicide-A 4μM R03 exp122	1.89
INK128 0.2μM R02 exp70	1.95
Nifuroxazide 5μM R03 exp102	1.95
Rapamycin 1μM R00 exp29	1.98
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.98
NFN1 1μM R03 exp100	2
Hippuristanol 0.12μM R08 exp488	2.24
Trimetrexate 0.03μM R08 exp535	2.33
Oligomycin-A 2μM R00 exp25	2.44
Rapamycin 0.001μM R08 exp429	2.88
Rapamycin 10μM R00 exp30	3.1

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
platelet dense tubular network
calcium ion transmembrane transporter activity
calcineurin complex
platelet dense granule membrane
voluntary musculoskeletal movement
epithelial fluid transport
platelet dense tubular network membrane
regulation of postsynaptic cytosolic calcium ion concentration
calcium channel inhibitor activity
calcium-release channel activity
inositol 1,4,5 trisphosphate binding
transepithelial transport
endoplasmic reticulum calcium ion homeostasis
inositol phosphate-mediated signaling
fluid transport
negative regulation of calcium-mediated signaling
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
transport vesicle membrane
multicellular organismal movement
musculoskeletal movement
sarcoplasmic reticulum
nuclear inner membrane
release of sequestered calcium ion into cytosol
negative regulation of sequestering of calcium ion
calcium ion transmembrane import into cytosol
regulation of cardiac conduction
calcium ion transport into cytosol
Schaffer collateral - CA1 synapse
phosphatidylinositol binding
cytosolic calcium ion transport
post-embryonic development
regulation of calcium-mediated signaling
secretory granule membrane
regulation of sequestering of calcium ion
platelet activation
cytoplasmic vesicle membrane
intrinsic apoptotic signaling pathway
regulation of insulin secretion