GNA15
Gene Information
- Official Symbol: GNA15
- Official Name: G protein subunit alpha 15
- Aliases and Previous Symbols: N/A
- Entrez ID: 2769
- UniProt: P30679
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Pfam Domains GO Terms
Pfam Domains
| G-alpha |
| Arf |
GO Terms
| phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway |
| phospholipase C-activating dopamine receptor signaling pathway |
| G protein-coupled acetylcholine receptor signaling pathway |
| G-protein beta/gamma-subunit complex binding |
| acetylcholine receptor signaling pathway |
| positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway |
| activation of phospholipase C activity |
| heterotrimeric G-protein complex |
| response to acetylcholine |
| cellular response to acetylcholine |
| dopamine receptor signaling pathway |
| postsynaptic signal transduction |
| positive regulation of phospholipase C activity |
| regulation of phospholipase C activity |
| positive regulation of phospholipase activity |
| G protein-coupled receptor binding |
| positive regulation of lipase activity |
| regulation of phospholipase activity |
| cellular response to dopamine |
| response to dopamine |
| signal transduction involved in cellular response to ammonium ion |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| regulation of lipase activity |
| cellular response to catecholamine stimulus |
| cellular response to monoamine stimulus |
| response to catecholamine |
| response to monoamine |
| cellular response to ammonium ion |
| platelet activation |
| response to ammonium ion |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| positive regulation of cytosolic calcium ion concentration |
| blood coagulation |
| coagulation |
| hemostasis |
| regulation of cytosolic calcium ion concentration |
| GTPase activity |
| GTP binding |
| cellular response to drug |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| synaptic signaling |
| cellular divalent inorganic cation homeostasis |
| wound healing |
| divalent inorganic cation homeostasis |
| regulation of body fluid levels |
| cellular response to organic cyclic compound |
| cellular metal ion homeostasis |
| response to wounding |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cellular response to nitrogen compound |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| positive regulation of hydrolase activity |
| ion homeostasis |
| cellular homeostasis |
| response to hormone |
| response to organic cyclic compound |
| response to organonitrogen compound |
| response to drug |
| cellular response to oxygen-containing compound |
| cell activation |
| response to nitrogen compound |
| chemical homeostasis |
| cell-cell signaling |
| cellular response to endogenous stimulus |
| regulation of hydrolase activity |
| G protein-coupled receptor signaling pathway |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| homeostatic process |
| positive regulation of molecular function |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11449
- Expression level (log2 read counts): 5.62
Expression Distribution
GNA15 Expression in NALM6 Cells: 5.62
