GNA15 [The Human Chemical-Genetic Interaction Map Project]

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======= GNA15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNA15
  * **<color #00a2e8>Official Name</color>**: G protein subunit alpha 15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2769|2769]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30679|P30679]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNA15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNA15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139314|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G-alpha|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway|
|phospholipase C-activating dopamine receptor signaling pathway|
|G protein-coupled acetylcholine receptor signaling pathway|
|G-protein beta/gamma-subunit complex binding|
|acetylcholine receptor signaling pathway|
|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|
|activation of phospholipase C activity|
|heterotrimeric G-protein complex|
|response to acetylcholine|
|cellular response to acetylcholine|
|dopamine receptor signaling pathway|
|postsynaptic signal transduction|
|positive regulation of phospholipase C activity|
|regulation of phospholipase C activity|
|positive regulation of phospholipase activity|
|G protein-coupled receptor binding|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|cellular response to dopamine|
|response to dopamine|
|signal transduction involved in cellular response to ammonium ion|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of lipase activity|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|response to catecholamine|
|response to monoamine|
|cellular response to ammonium ion|
|platelet activation|
|response to ammonium ion|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|positive regulation of cytosolic calcium ion concentration|
|blood coagulation|
|coagulation|
|hemostasis|
|regulation of cytosolic calcium ion concentration|
|GTPase activity|
|GTP binding|
|cellular response to drug|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|wound healing|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|cellular response to organic cyclic compound|
|cellular metal ion homeostasis|
|response to wounding|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|ion homeostasis|
|cellular homeostasis|
|response to hormone|
|response to organic cyclic compound|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|chemical homeostasis|
|cell-cell signaling|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.97|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.94|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.73|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.77|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.85|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.05|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.08|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.53|
|[[:human genes:p:ppp3ca|PPP3CA]]|0.523|
|[[:human genes:p:ppp3r1|PPP3R1]]|0.474|
|[[:human genes:p:prim1|PRIM1]]|0.447|
|[[:human genes:i:itpr1|ITPR1]]|0.432|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.429|
|[[:human genes:l:lpar5|LPAR5]]|0.42|
|[[:human genes:e:ergic1|ERGIC1]]|0.41|
|[[:human genes:c:cd79b|CD79B]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11449
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNA15 Expression in NALM6 Cells: 5.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>