STMN1
Gene Information
- Official Symbol: STMN1
- Official Name: stathmin 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3925
- UniProt: P16949
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Stathmin |
GO Terms
| negative regulation of thrombin-activated receptor signaling pathway |
| regulation of thrombin-activated receptor signaling pathway |
| negative regulation of guanyl-nucleotide exchange factor activity |
| regulation of guanyl-nucleotide exchange factor activity |
| hepatocyte growth factor receptor signaling pathway |
| regulation of GTP binding |
| negative regulation of microtubule polymerization |
| microtubule depolymerization |
| negative regulation of stress fiber assembly |
| negative regulation of Rho protein signal transduction |
| establishment of skin barrier |
| negative regulation of actin filament bundle assembly |
| regulation of water loss via skin |
| protein depolymerization |
| negative regulation of microtubule polymerization or depolymerization |
| negative regulation of G protein-coupled receptor signaling pathway |
| microtubule polymerization or depolymerization |
| regulation of microtubule polymerization |
| negative regulation of Ras protein signal transduction |
| tubulin binding |
| negative regulation of small GTPase mediated signal transduction |
| negative regulation of protein polymerization |
| multicellular organismal water homeostasis |
| mitotic cytokinesis |
| water homeostasis |
| mitotic spindle organization |
| regulation of stress fiber assembly |
| regulation of microtubule polymerization or depolymerization |
| intracellular |
| regulation of actomyosin structure organization |
| regulation of actin filament bundle assembly |
| cytoskeleton-dependent cytokinesis |
| cytokinesis |
| negative regulation of protein binding |
| microtubule cytoskeleton organization involved in mitosis |
| negative regulation of protein complex assembly |
| negative regulation of supramolecular fiber organization |
| cellular protein complex disassembly |
| negative regulation of cytoskeleton organization |
| regulation of Rho protein signal transduction |
| regulation of G protein-coupled receptor signaling pathway |
| spindle organization |
| negative regulation of binding |
| positive regulation of binding |
| regulation of microtubule cytoskeleton organization |
| regulation of protein binding |
| regulation of microtubule-based process |
| regulation of protein polymerization |
| protein-containing complex disassembly |
| regulation of Ras protein signal transduction |
| regulation of actin filament organization |
| response to virus |
| microtubule |
| neuron projection |
| multicellular organismal homeostasis |
| regulation of actin cytoskeleton organization |
| regulation of small GTPase mediated signal transduction |
| regulation of supramolecular fiber organization |
| axonogenesis |
| negative regulation of organelle organization |
| regulation of binding |
| skin development |
| regulation of actin filament-based process |
| cellular component disassembly |
| axon development |
| cell morphogenesis involved in neuron differentiation |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| microtubule cytoskeleton organization |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| cell division |
| regulation of body fluid levels |
| negative regulation of intracellular signal transduction |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cell part morphogenesis |
| positive regulation of cellular component movement |
| regulation of cytoskeleton organization |
| cell morphogenesis involved in differentiation |
| mitotic cell cycle process |
| neuron projection development |
| microtubule-based process |
| mitotic cell cycle |
| negative regulation of cellular component organization |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| brain development |
| head development |
| neuron development |
| cellular component morphogenesis |
| regulation of cellular component biogenesis |
| central nervous system development |
| regulation of cellular component movement |
| cell cycle process |
| neuron differentiation |
| cytoskeleton organization |
| chemical homeostasis |
| plasma membrane bounded cell projection organization |
| negative regulation of molecular function |
| cell projection organization |
| negative regulation of signal transduction |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| generation of neurons |
| negative regulation of response to stimulus |
| neurogenesis |
| homeostatic process |
| cell development |
| intracellular signal transduction |
| positive regulation of molecular function |
| regulation of intracellular signal transduction |
| protein-containing complex subunit organization |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12265
- Expression level (log2 read counts): 9.32
Expression Distribution
STMN1 Expression in NALM6 Cells: 9.32
