STMN1 [The Human Chemical-Genetic Interaction Map Project]

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======= STMN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STMN1
  * **<color #00a2e8>Official Name</color>**: stathmin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3925|3925]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16949|P16949]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STMN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STMN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/151442|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Stathmin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of thrombin-activated receptor signaling pathway|
|regulation of thrombin-activated receptor signaling pathway|
|negative regulation of guanyl-nucleotide exchange factor activity|
|regulation of guanyl-nucleotide exchange factor activity|
|hepatocyte growth factor receptor signaling pathway|
|regulation of GTP binding|
|negative regulation of microtubule polymerization|
|microtubule depolymerization|
|negative regulation of stress fiber assembly|
|negative regulation of Rho protein signal transduction|
|establishment of skin barrier|
|negative regulation of actin filament bundle assembly|
|regulation of water loss via skin|
|protein depolymerization|
|negative regulation of microtubule polymerization or depolymerization|
|negative regulation of G protein-coupled receptor signaling pathway|
|microtubule polymerization or depolymerization|
|regulation of microtubule polymerization|
|negative regulation of Ras protein signal transduction|
|tubulin binding|
|negative regulation of small GTPase mediated signal transduction|
|negative regulation of protein polymerization|
|multicellular organismal water homeostasis|
|mitotic cytokinesis|
|water homeostasis|
|mitotic spindle organization|
|regulation of stress fiber assembly|
|regulation of microtubule polymerization or depolymerization|
|intracellular|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|negative regulation of protein binding|
|microtubule cytoskeleton organization involved in mitosis|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|cellular protein complex disassembly|
|negative regulation of cytoskeleton organization|
|regulation of Rho protein signal transduction|
|regulation of G protein-coupled receptor signaling pathway|
|spindle organization|
|negative regulation of binding|
|positive regulation of binding|
|regulation of microtubule cytoskeleton organization|
|regulation of protein binding|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|protein-containing complex disassembly|
|regulation of Ras protein signal transduction|
|regulation of actin filament organization|
|response to virus|
|microtubule|
|neuron projection|
|multicellular organismal homeostasis|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|axonogenesis|
|negative regulation of organelle organization|
|regulation of binding|
|skin development|
|regulation of actin filament-based process|
|cellular component disassembly|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell division|
|regulation of body fluid levels|
|negative regulation of intracellular signal transduction|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|cell morphogenesis involved in differentiation|
|mitotic cell cycle process|
|neuron projection development|
|microtubule-based process|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|cellular component morphogenesis|
|regulation of cellular component biogenesis|
|central nervous system development|
|regulation of cellular component movement|
|cell cycle process|
|neuron differentiation|
|cytoskeleton organization|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|negative regulation of signal transduction|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|generation of neurons|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|cell development|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-4.93|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-4.4|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-4.39|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-4.27|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-4.07|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-3.47|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-3.38|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-3.35|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.51|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.39|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.37|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-2.2|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.16|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.16|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.07|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.02|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.95|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.87|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.86|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.79|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.77|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.76|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.76|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.73|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.73|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.71|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:ska1|SKA1]]|0.485|
|[[:human genes:t:tubb|TUBB]]|0.477|
|[[:human genes:p:pfdn5|PFDN5]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12265
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STMN1 Expression in NALM6 Cells: 9.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>