AGPAT9

Entrez Summary: N/A
UniProt Summary: May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid, or PA). {ECO:0000269|PubMed:17002884, ECO:0000269|PubMed:17170135, ECO:0000269|PubMed:19318427}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Adefovir 20μM R07 exp332	-1.85
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	2.08
Aphidicolin 0.4μM R08 exp440	2.16

sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity
glycerol-3-phosphate O-acyltransferase activity
CDP-diacylglycerol biosynthetic process
CDP-diacylglycerol metabolic process
1-acylglycerol-3-phosphate O-acyltransferase activity
triglyceride biosynthetic process
acylglycerol biosynthetic process
neutral lipid biosynthetic process
phosphatidic acid biosynthetic process
phosphatidic acid metabolic process
pyrimidine nucleotide biosynthetic process
pyrimidine-containing compound biosynthetic process
pyrimidine nucleotide metabolic process
triglyceride metabolic process
acylglycerol metabolic process
neutral lipid metabolic process
regulation of TOR signaling
pyrimidine-containing compound metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
nucleotide biosynthetic process
phospholipid biosynthetic process
nucleoside phosphate biosynthetic process
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
lipid biosynthetic process
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
endoplasmic reticulum
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
lipid metabolic process
organic cyclic compound biosynthetic process