MASTL

Entrez Summary: This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Feb 2010].
UniProt Summary: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 726/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	31/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	19/20
lung	75/75
lymphocyte	16/16
ovary	22/26
pancreas	23/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	0/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	4/5

Expression Distribution

Pkinase
Pkinase Tyr

female meiosis II
meiosis II cell cycle process
meiosis II
positive regulation of ubiquitin protein ligase activity
regulation of ubiquitin protein ligase activity
female meiotic nuclear division
positive regulation of ubiquitin-protein transferase activity
protein phosphatase 2A binding
regulation of ubiquitin-protein transferase activity
cleavage furrow
negative regulation of phosphoprotein phosphatase activity
negative regulation of protein dephosphorylation
kinase activity
negative regulation of phosphatase activity
negative regulation of dephosphorylation
positive regulation of protein ubiquitination
regulation of phosphoprotein phosphatase activity
female gamete generation
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
positive regulation of protein modification by small protein conjugation or removal
regulation of protein dephosphorylation
meiotic nuclear division
meiotic cell cycle process
peptidyl-serine phosphorylation
regulation of phosphatase activity
peptidyl-serine modification
regulation of protein ubiquitination
regulation of dephosphorylation
meiotic cell cycle
regulation of protein modification by small protein conjugation or removal
mitotic cell cycle phase transition
cell cycle phase transition
nuclear division
organelle fission
cellular process involved in reproduction in multicellular organism
protein serine/threonine kinase activity
negative regulation of hydrolase activity
centrosome
cell division