HMGCS2

Entrez Summary: The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
UniProt Summary: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

HMG CoA synt C
HMG CoA synt N

farnesyl diphosphate biosynthetic process, mevalonate pathway
isoprenoid biosynthetic process via mevalonate
hydroxymethylglutaryl-CoA synthase activity
farnesyl diphosphate biosynthetic process
farnesyl diphosphate metabolic process
ketone body biosynthetic process
cellular ketone body metabolic process
ketone body metabolic process
terpenoid biosynthetic process
isoprenoid biosynthetic process
acetyl-CoA metabolic process
cholesterol biosynthetic process
secondary alcohol biosynthetic process
sterol biosynthetic process
fatty acid derivative biosynthetic process
acyl-CoA metabolic process
thioester metabolic process
alcohol biosynthetic process
cholesterol metabolic process
terpenoid metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
sterol metabolic process
isoprenoid metabolic process
fatty acid derivative metabolic process
organic hydroxy compound biosynthetic process
phospholipid biosynthetic process
coenzyme metabolic process
steroid metabolic process
purine ribonucleotide metabolic process
alcohol metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
sulfur compound metabolic process
purine-containing compound metabolic process
mitochondrial matrix