SLC52A2

Gene Information

Official Symbol: SLC52A2
Official Name: solute carrier family 52 member 2
Aliases and Previous Symbols: N/A
Entrez ID: 79581
UniProt: Q9HAB3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a membrane protein which belongs to the riboflavin transporter family. In humans, riboflavin must be obtained by intestinal absorption because it cannot be synthesized by the body. The water-soluble vitamin riboflavin is processed to the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) which then act as intermediaries in many cellular metabolic reactions. Paralogous members of the riboflavin transporter gene family are located on chromosomes 17 and 20. Unlike other members of this family, this gene has higher expression in brain tissue than small intestine. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene have been associated with Brown-Vialetto-Van Laere syndrome 2 - an autosomal recessive progressive neurologic disorder characterized by deafness, bulbar dysfunction, and axial and limb hypotonia. [provided by RefSeq, Jul 2012].
UniProt Summary: Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A). {ECO:0000269|PubMed:12740431, ECO:0000269|PubMed:19307586, ECO:0000269|PubMed:20463145, ECO:0000269|PubMed:22864630, ECO:0000269|PubMed:23243084, ECO:0000269|PubMed:24253200, ECO:0000269|PubMed:27702554}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Quercetin 20μM R08 exp517	-2.52
A-196 10μM R03 exp114	-2.44
SB203580 25μM R03 exp149	-2.1
QNZ 0.01μM R05 exp241	-1.95
Epigallocatechin gallate 20μM R05 exp230	-1.78
Cycloheximide 0.2μM R00 exp15	1.84
Wortmannin 5μM R00 exp38	1.85
Cycloheximide 0.02μM R00 exp14	1.88
Artemisinin 50μM R08 exp450	2.41
Mitomycin-C 0.06μM R08 exp503	4.39

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2251
Expression level (log2 read counts): 6.26

Expression Distribution

4-hydroxybutyrate receptor activity
riboflavin transmembrane transporter activity
riboflavin transport
riboflavin metabolic process
flavin-containing compound metabolic process
vitamin transport
virus receptor activity
water-soluble vitamin metabolic process
viral entry into host cell
entry into host cell
entry into host
vitamin metabolic process
drug transport
interaction with host
viral life cycle
organic anion transport
drug metabolic process
anion transport
viral process
symbiotic process
interspecies interaction between organisms
response to drug
ion transport
integral component of plasma membrane
small molecule metabolic process
nitrogen compound transport