KIF18A

Entrez Summary: N/A
UniProt Summary: Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. {ECO:0000269|PubMed:17346968, ECO:0000269|PubMed:18267093, ECO:0000269|PubMed:18513970, ECO:0000269|PubMed:19625775}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK461364A 0.005μM R03 exp125	-5.81
BI-6727 0.0125μM R03 exp97	-4.6
BI-2536 0.0042μM R03 exp95	-4.36
BML-284 0.09μM R08 exp460	-4.14
B02 10μM R08 exp453	-3.32
Parthenolide 2.5μM R05 exp238	-3.31
Mdivi-1 15μM R05 exp217	-2.89
BI-D1870 2μM R04 exp162	-2.73
GSK626616 14μM R08 exp485	-2.65
LLY-283 2.6μM R06 exp290	-2.6
LB-100 2μM R05 exp210	-2.52
Arsenic trioxide 60μM R08 exp449	-2.31
Resveratrol 16μM R03 exp147	-2.14
3-Bromopyruvate 7μM R04 exp175	-2.13
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-2.12
CAY10603 0.55μM R08 exp467	-2.11
Quinacrine 2.5μM R03 exp146	-2.11
UMK57 0.6μM R03 exp107	-2.1
GSK591 2.6μM R03 exp128	-2.07
Arsenate 40μM R06 exp264	-2.02
Vincristine 0.0005μM R04 exp190	-1.96
UMK57 1μM R01 exp59	-1.95
Curcumin 6.5μM R06 exp277	-1.88
Momordin-Ic 10μM R08 exp506	1.84

Global Fraction of Cell Lines Where Essential: 524/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	22/28
blood	13/28
bone	17/26
breast	21/33
central nervous system	45/56
cervix	3/4
colorectal	12/17
esophagus	7/13
fibroblast	1/1
gastric	10/16
kidney	18/21
liver	17/20
lung	49/75
lymphocyte	14/16
ovary	17/26
pancreas	20/24
peripheral nervous system	14/16
plasma cell	6/15
prostate	1/1
skin	17/24
soft tissue	7/9
thyroid	1/2
upper aerodigestive	20/22
urinary tract	25/29
uterus	5/5

Expression Distribution

tubulin-dependent ATPase activity
mitotic spindle astral microtubule
kinetochore microtubule
seminiferous tubule development
mitotic spindle midzone
microtubule plus-end binding
microtubule depolymerization
ATP-dependent microtubule motor activity, plus-end-directed
protein depolymerization
cellular response to estradiol stimulus
mitotic metaphase plate congression
male meiotic nuclear division
microtubule polymerization or depolymerization
kinesin complex
metaphase plate congression
microtubule motor activity
establishment of chromosome localization
chromosome localization
caveola
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
kinetochore
ruffle
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
mitotic sister chromatid segregation
male gonad development
development of primary male sexual characteristics
response to estradiol
cellular protein complex disassembly
sister chromatid segregation
mitotic nuclear division
meiotic nuclear division
microtubule cytoskeleton
male sex differentiation
microtubule organizing center
meiotic cell cycle process
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
regulation of microtubule cytoskeleton organization