WDR66

Entrez Summary: This protein encoded by this gene belongs to the WD repeat-containing family of proteins, which function in the formation of protein-protein complexes in a variety of biological pathways. This family member appears to function in the determination of mean platelet volume (MPV), and polymorphisms in this gene have been associated with variance in MPV. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2011].
UniProt Summary: May regulate cilium motility through its role in the assembly of the axonemal radial spokes. {ECO:0000250|UniProtKB:A8IRK7, ECO:0000250|UniProtKB:Q24DE2}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
35°C R06 exp302	-2.1
Curcumin 6.5μM R06 exp277	-2
Trichostatin-A 0.06μM R07 exp415	-1.74
Prochlorperazine 5.2μM R02 exp77	-1.73
42°C R08 exp539	1.7
CAY10603 0.55μM R08 exp467	1.77
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	1.85
BML-284 0.09μM R08 exp460	1.86
Dihydrosphingosine 8μM R08 exp476	2.26
Amiloride 100μM R08 exp447	2.58

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

radial spoke stalk
sperm flagellum
cilium movement
flagellated sperm motility
sperm motility
cilium-dependent cell motility
cilium or flagellum-dependent cell motility
motile cilium
axoneme
microtubule-based movement
microtubule-based process
localization of cell
cell motility
locomotion
reproductive process
reproduction
movement of cell or subcellular component