DTYMK [The Human Chemical-Genetic Interaction Map Project]

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======= DTYMK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DTYMK
  * **<color #00a2e8>Official Name</color>**: deoxythymidylate kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1841|1841]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23919|P23919]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DTYMK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DTYMK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/188345|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the conversion of dTMP to dTDP.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thymidylate kin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dTDP biosynthetic process|
|pyrimidine deoxyribonucleoside biosynthetic process|
|pyrimidine deoxyribonucleoside diphosphate metabolic process|
|thymidylate kinase activity|
|pyrimidine nucleoside diphosphate biosynthetic process|
|pyrimidine deoxyribonucleoside diphosphate biosynthetic process|
|dUDP metabolic process|
|dTDP metabolic process|
|dUDP biosynthetic process|
|thymidine biosynthetic process|
|deoxyribonucleoside biosynthetic process|
|pyrimidine nucleoside diphosphate metabolic process|
|uridylate kinase activity|
|dTTP biosynthetic process|
|pyrimidine deoxyribonucleoside triphosphate biosynthetic process|
|deoxyribonucleoside diphosphate biosynthetic process|
|pyrimidine deoxyribonucleoside metabolic process|
|dTTP metabolic process|
|thymidine metabolic process|
|deoxyribonucleoside diphosphate metabolic process|
|deoxyribonucleoside triphosphate biosynthetic process|
|pyrimidine deoxyribonucleoside triphosphate metabolic process|
|deoxyribonucleoside metabolic process|
|pyrimidine deoxyribonucleotide biosynthetic process|
|nucleoside diphosphate biosynthetic process|
|deoxyribose phosphate biosynthetic process|
|2-deoxyribonucleotide biosynthetic process|
|nucleoside monophosphate phosphorylation|
|deoxyribonucleotide biosynthetic process|
|pyrimidine nucleoside biosynthetic process|
|deoxyribonucleoside triphosphate metabolic process|
|pyrimidine nucleoside triphosphate biosynthetic process|
|nucleoside diphosphate kinase activity|
|pyrimidine deoxyribonucleotide metabolic process|
|pyrimidine nucleoside triphosphate metabolic process|
|nucleobase-containing small molecule interconversion|
|2-deoxyribonucleotide metabolic process|
|deoxyribose phosphate metabolic process|
|myoblast differentiation|
|deoxyribonucleotide metabolic process|
|pyrimidine nucleoside metabolic process|
|nucleoside biosynthetic process|
|glycosyl compound biosynthetic process|
|pyrimidine nucleotide biosynthetic process|
|pyrimidine-containing compound biosynthetic process|
|nucleoside diphosphate phosphorylation|
|nucleotide phosphorylation|
|pyrimidine nucleotide metabolic process|
|nucleoside triphosphate biosynthetic process|
|response to cadmium ion|
|nucleoside monophosphate metabolic process|
|response to estrogen|
|mitochondrial intermembrane space|
|nucleoside diphosphate metabolic process|
|nucleoside triphosphate metabolic process|
|pyrimidine-containing compound metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|nucleoside metabolic process|
|glycosyl compound metabolic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|mitochondrial matrix|
|response to metal ion|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|muscle structure development|
|cellular response to growth factor stimulus|
|response to growth factor|
|response to inorganic substance|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.29|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.2|
|[[:results:exp218|A-395 10μM R05 exp218]]|-2.19|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-2.02|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.01|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-2.01|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.94|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.8|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.76|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.76|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.74|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.7|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.72|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 683/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|28/28|
|blood|28/28|
|bone|21/26|
|breast|32/33|
|central nervous system|43/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|20/21|
|liver|16/20|
|lung|70/75|
|lymphocyte|16/16|
|ovary|21/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|1/2|
|upper aerodigestive|21/22|
|urinary tract|26/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 36
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DTYMK Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>