KCTD10

Entrez Summary: N/A
UniProt Summary: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity). {ECO:0000250|UniProtKB:Q8WZ19}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Staurosporine 0.02μM R08 exp524	-2.56
Dinaciclib 0.007μM R07 exp355	-2.09
Wiskostatin 3μM R07 exp422	-2
CR131-b 0.005μM R08 exp474	-1.83
Pyronaridine 1μM R06 exp295	-1.78
Temozolomide 200μM R04 exp189	1.71
Trimetrexate 0.03μM R08 exp535	1.71
Citral 50μM R06 exp274	1.77
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.83
LB-100 2μM R05 exp210	3.33
LB-100 4.1μM R02 exp72	7.1

Global Fraction of Cell Lines Where Essential: 57/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	1/28
bone	5/26
breast	6/33
central nervous system	5/56
cervix	1/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	3/21
liver	2/20
lung	6/75
lymphocyte	0/16
ovary	2/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	1/2
upper aerodigestive	0/22
urinary tract	5/29
uterus	1/5

Expression Distribution

GTP-Rho binding
negative regulation of Rho protein signal transduction
Notch binding
Cul3-RING ubiquitin ligase complex
negative regulation of Ras protein signal transduction
negative regulation of small GTPase mediated signal transduction
regulation of Rho protein signal transduction
regulation of Ras protein signal transduction
ubiquitin-protein transferase activity
proteasome-mediated ubiquitin-dependent protein catabolic process
protein homooligomerization
regulation of small GTPase mediated signal transduction
proteasomal protein catabolic process
negative regulation of intracellular signal transduction
protein complex oligomerization
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
protein modification by small protein conjugation
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
negative regulation of signal transduction
proteolysis
negative regulation of cell communication
negative regulation of signaling
protein-containing complex assembly
negative regulation of response to stimulus
organic substance catabolic process
cellular catabolic process
regulation of intracellular signal transduction
protein-containing complex subunit organization