KCTD10 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= KCTD10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCTD10
  * **<color #00a2e8>Official Name</color>**: potassium channel tetramerization domain containing 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83892|83892]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H3F6|Q9H3F6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCTD10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCTD10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613421|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity). {ECO:0000250|UniProtKB:Q8WZ19}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|K tetra|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GTP-Rho binding|
|negative regulation of Rho protein signal transduction|
|Notch binding|
|Cul3-RING ubiquitin ligase complex|
|negative regulation of Ras protein signal transduction|
|negative regulation of small GTPase mediated signal transduction|
|regulation of Rho protein signal transduction|
|regulation of Ras protein signal transduction|
|ubiquitin-protein transferase activity|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|protein homooligomerization|
|regulation of small GTPase mediated signal transduction|
|proteasomal protein catabolic process|
|negative regulation of intracellular signal transduction|
|protein complex oligomerization|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|protein modification by small protein conjugation|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|negative regulation of signal transduction|
|proteolysis|
|negative regulation of cell communication|
|negative regulation of signaling|
|protein-containing complex assembly|
|negative regulation of response to stimulus|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-2.56|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.09|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-2|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.83|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.78|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.71|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.71|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.77|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.83|
|[[:results:exp210|LB-100 2μM R05 exp210]]|3.33|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|7.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pebp1|PEBP1]]|0.434|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 57/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|5/26|
|breast|6/33|
|central nervous system|5/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|3/21|
|liver|2/20|
|lung|6/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3628
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCTD10 Expression in NALM6 Cells: 5.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>