Wiskostatin 3μM R07 exp422 [The Human Chemical-Genetic Interaction Map Project]

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====== Wiskostatin 3μM R07 exp422 ======
==== Mechanism of Action ====
Inhibits N-WASP, blocks actin polymerization
  * **<color #00a2e8>Class / Subclass 1:</color>** Organelle Function / Cytoskeletal Inhibitor
  * **<color #00a2e8>Class / Subclass 2:</color>** Cell Cycle / Actin Inhibitor



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Wiskostatin%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 253449-04-6
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/2775510|2775510]]
    * **<color #00a2e8>IUPAC:</color>** %%1-(3,6-dibromocarbazol-9-yl)-3-(dimethylamino)propan-2-ol%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C17H18Br2N2O/c1-20(2)9-13(22)10-21-16-5-3-11(18)7-14(16)15-8-12(19)4-6-17(15)21/h3-8,13,22H,9-10H2,1-2H3
    * **<color #00a2e8>INCHI Key:</color>** XUBJEDZHBUPBKL-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 426.1
    * **<color #00a2e8>Canonical SMILES:</color>** CN(C)CC(CN1C2=C(C=C(C=C2)Br)C3=C1C=CC(=C3)Br)O
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C17H18Br2N2O
{{:chemogenomics:structures:chem-0253.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Toronto Research Chemicals
    * **<color #00a2e8>Catalog #:</color>** W498925
    * **<color #00a2e8>Lot #:</color>** 7-MWC-89-1
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C17H18Br2N2O 424.98587; found 424.98566
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Wiskostatin
    * **<color #00a2e8>Min:</color>** -1.6934; **<color #00a2e8>Max:</color>** 99.8632
{{:chemogenomics:dose_response:dr_413.png?nolink&500 |}}
\\ 
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |2.2422    |
| IC30  |2.8245    |
| IC40  |3.4258    |
| IC50  |4.0977    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 07
    * **<color #00a2e8>Dose</color>**: 3µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 6.5
    * **<color #00a2e8>Numbers of reads</color>**: 18623672


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|7/1|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Wiskostatin_3uM_Round-7_exp422.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Wiskostatin 3μM R07 exp422'>
{{:chemogenomics:cranks_plots:exp422.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:F:FLVCR1|FLVCR1]]|-3.49|<0.01|
|[[:human_genes:A:ARL1|ARL1]]|-3.11|<0.01|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-3.11|<0.01|
|[[:human_genes:C:CHKA|CHKA]]|-2.77|0.02|
|[[:human_genes:R:RGP1|RGP1]]|-2.75|0.04|
|[[:human_genes:A:ACSL4|ACSL4]]|-2.65|0.03|
|[[:human_genes:R:RSRC2|RSRC2]]|-2.55|0.50|
|[[:human_genes:R:RAB7A|RAB7A]]|-2.52|0.05|
|[[:human_genes:S:SCYL1|SCYL1]]|-2.45|0.06|
|[[:human_genes:K:KDSR|KDSR]]|-2.35|0.10|
|[[:human_genes:H:H2AFZ|H2AFZ]]|-2.34|0.10|
|[[:human_genes:E:ERGIC3|ERGIC3]]|-2.27|0.13|
|[[:human_genes:A:ARFRP1|ARFRP1]]|-2.27|0.19|
|[[:human_genes:P:PIK3R4|PIK3R4]]|-2.21|0.24|
|[[:human_genes:T:TCHP|TCHP]]|-2.20|0.61|
|[[:human_genes:T:TSSC1|TSSC1]]|-2.18|0.18|
|[[:human_genes:F:FBXO11|FBXO11]]|-2.17|0.18|
|[[:human_genes:S:SETX|SETX]]|-2.17|0.28|
|[[:human_genes:G:GPR107|GPR107]]|-2.17|0.18|
|[[:human_genes:P:PGGT1B|PGGT1B]]|-2.16|0.18|
|[[:human_genes:S:SPATA4|SPATA4]]|-2.12|0.20|
|[[:human_genes:S:SCD|SCD]]|-2.11|0.32|
|[[:human_genes:K:KDM8|KDM8]]|-2.04|0.33|
|[[:human_genes:D:DTYMK|DTYMK]]|-2.02|0.33|
|[[:human_genes:K:KCTD10|KCTD10]]|-2.00|0.32|
|[[:human_genes:C:CCL1|CCL1]]|-1.99|0.32|
|[[:human_genes:S:SUMO2|SUMO2]]|-1.99|0.64|
|[[:human_genes:T:TOP3A|TOP3A]]|-1.98|0.32|
|[[:human_genes:T:THG1L|THG1L]]|-1.98|0.32|
|[[:human_genes:C:CDH22|CDH22]]|-1.97|0.33|
|[[:human_genes:S:SLC35G2|SLC35G2]]|1.93|0.53|
|[[:human_genes:Z:ZNF621|ZNF621]]|1.94|0.53|
|[[:human_genes:M:MRPL50|MRPL50]]|1.95|0.53|
|[[:human_genes:S:SH3GLB2|SH3GLB2]]|1.95|0.53|
|[[:human_genes:R:RNF121|RNF121]]|1.97|0.70|
|[[:human_genes:F:FAM71D|FAM71D]]|1.97|0.53|
|[[:human_genes:R:RRN3|RRN3]]|1.99|0.53|
|[[:human_genes:D:DDIT3|DDIT3]]|1.99|0.54|
|[[:human_genes:L:LTBP4|LTBP4]]|2.03|0.62|
|[[:human_genes:F:FAM117A|FAM117A]]|2.04|0.48|
|[[:human_genes:F:FIBP|FIBP]]|2.04|0.48|
|[[:human_genes:E:EIF5B|EIF5B]]|2.05|0.77|
|[[:human_genes:C:CGNL1|CGNL1]]|2.05|0.53|
|[[:human_genes:G:GLTSCR2|GLTSCR2]]|2.08|0.57|
|[[:human_genes:R:RPS9|RPS9]]|2.08|0.77|
|[[:human_genes:D:DST|DST]]|2.11|0.43|
|[[:human_genes:T:TOPBP1|TOPBP1]]|2.11|0.56|
|[[:human_genes:H:HHLA2|HHLA2]]|2.14|0.43|
|[[:human_genes:M:MYC|MYC]]|2.19|0.77|
|[[:human_genes:D:DRD3|DRD3]]|2.19|0.41|
|[[:human_genes:I:IMPG1|IMPG1]]|2.22|0.41|
|[[:human_genes:R:RNF111|RNF111]]|2.22|0.43|
|[[:human_genes:F:FCGRT|FCGRT]]|2.22|0.43|
|[[:human_genes:O:OR13C9|OR13C9]]|2.23|0.41|
|[[:human_genes:L:LRRC63|LRRC63]]|2.24|0.77|
|[[:human_genes:Q:QTRT1|QTRT1]]|2.43|0.22|
|[[:human_genes:C:CKAP5|CKAP5]]|2.51|0.54|
|[[:human_genes:D:DDX46|DDX46]]|2.73|0.75|
|[[:human_genes:R:RPS13|RPS13]]|2.95|0.22|
|[[:human_genes:C:C4orf51|C4orf51]]|3.03|0.02|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|0.096|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|0.085|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp149|SB203580 25μM R03 exp149]]|0.083|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp483|FTY720 3μM R08 exp483]]|0.08|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|0.078|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|0.077|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.072|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|0.071|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp358|FK-506 5μM R07 exp358]]|0.07|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|0.067|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|0.064|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|0.064|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|0.062|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|0.06|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|0.057|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|0.057|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|0.056|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|0.056|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|0.054|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|0.053|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|0.051|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|0.051|<button type="primary" size="small" modal="22">View</button>|
</modal>


<modal id="1" size="lg" title="Thioridazine 5μM R08 exp530  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp422_vs_exp530.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp344_vs_exp422.png?nolink |}}
</modal>

<modal id="3" size="lg" title="SB203580 25μM R03 exp149  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp149_vs_exp422.png?nolink |}}
</modal>

<modal id="4" size="lg" title="FTY720 3μM R08 exp483  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp422_vs_exp483.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Bisphenol F 50μM R08 exp457  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp422_vs_exp457.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Prochlorperazine 5.2μM R02 exp77  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp422_vs_exp77.png?nolink |}}
</modal>

<modal id="7" size="lg" title="BS-181 20μM R08 exp461  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp422_vs_exp461.png?nolink |}}
</modal>

<modal id="8" size="lg" title="CCT251545 20μM R07 exp326  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp326_vs_exp422.png?nolink |}}
</modal>

<modal id="9" size="lg" title="FK-506 5μM R07 exp358  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp358_vs_exp422.png?nolink |}}
</modal>

<modal id="10" size="lg" title="IU1-47 25μM R04 exp182  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp182_vs_exp422.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Ibrutinib 10μM R08 exp442  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp422_vs_exp442.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Bisphenol A 100μM R06 exp269  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp269_vs_exp422.png?nolink |}}
</modal>

<modal id="13" size="lg" title="CAY10603 0.55μM R08 exp467  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp422_vs_exp467.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Lapatinib 5μM R01 exp47  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp422_vs_exp47.png?nolink |}}
</modal>

<modal id="15" size="lg" title="EPZ-5676 30μM R05 exp233  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp233_vs_exp422.png?nolink |}}
</modal>

<modal id="16" size="lg" title="NN-Dimethylsphingosine 2.5μM R08 exp508  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp422_vs_exp508.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Q15 1 to 2μM on day4 R04 exp164  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp164_vs_exp422.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Cyclosporin-A 3μM R07 exp348  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp348_vs_exp422.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Momordin-Ic 10μM R08 exp506  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp422_vs_exp506.png?nolink |}}
</modal>

<modal id="20" size="lg" title="SGC0946 7μM R03 exp151  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp151_vs_exp422.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Myriocin 25μM R06 exp293  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp293_vs_exp422.png?nolink |}}
</modal>

<modal id="22" size="lg" title="Caffeine 2600μM R08 exp463  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp422_vs_exp463.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>