EIF5B

Entrez Summary: N/A
UniProt Summary: Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes. {ECO:0000250|UniProtKB:P39730}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
DABN racemic mixture R03 exp93	-2.87
Rotenone 20μM R00 exp34	-2.6
Calcium Ionophore 0.4μM R07 exp342	-2.44
Rapamycin 10μM R00 exp30	-2.44
Nutlin-3A 1.6μM R06 exp294	-2.38
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-2.32
BI-2536 0.02μM R03 exp96	-2.12
Tubacin 1.6μM R07 exp416	-2.09
Rapamycin 2μM R07 exp306	-1.94
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-1.79
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.7
NFN1 0.4μM R03 exp99	1.71
Nicotinamide 2000μM R01 exp50	1.81
ABT-702 5μM R06 exp261	1.89
SGC2096 2.6μM R03 exp153	1.9
Nifuroxazide 5μM R03 exp102	1.95
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.99
Lapatinib 5μM R01 exp47	2.02
Docetaxel 0.002μM R01 exp45	2.03
Wiskostatin 3μM R07 exp422	2.05
Docosahexaenoic-acid 50μM R07 exp356	2.1
YM155 0.0002μM R01 exp61	2.14
Zebularine 20μM R07 exp423	2.14
Nifurtimox 1μM R03 exp141	2.21
Tozasertib 0.1μM R07 exp414	2.35
SB203580 25μM R03 exp149	2.37
Q15 1 to 2μM on day4 R04 exp164	2.57
Golgicide-A 2μM R03 exp121	2.6
UMK57 0.6μM R03 exp107	2.65

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

translation initiation factor activity
regulation of translational initiation
translational initiation
GTPase activity
regulation of translation
translation
GTP binding
regulation of cellular amide metabolic process
peptide biosynthetic process
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
RNA binding
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression