H2AFZ

Entrez Summary: N/A
UniProt Summary: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. {ECO:0000269|PubMed:15878876}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Wiskostatin 3μM R07 exp422	-2.34
Docetaxel 0.002μM R01 exp45	-1.71
AICAR 240μM R03 exp116	1.72
I-BRD9 4μM R07 exp365	1.74
Staurosporine 0.02μM R08 exp524	1.74
ONC212 0.15μM R08 exp513	1.78
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.78
Fluvastatin 2.2μM R06 exp282	1.8
VER-155008 3.9μM R06 exp301	1.82
iCRT14 30μM R08 exp492	1.86
Citral 75μM R06 exp275	1.87
Aphidicolin 0.4μM R08 exp440	1.95
Arsenate 40μM R06 exp264	1.96
QNZ 0.01μM R08 exp439	1.97
Benzoate 20000μM R08 exp456	2.01
Dorsomorphin 5μM R07 exp357	2.01
Milciclib 2μM R08 exp502	2.03
Deguelin 0.15μM R05 exp209	2.11
BI-D1870 3.15μM R02 exp66	2.17
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	2.22
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	2.29
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.32
Hippuristanol 0.12μM R08 exp488	2.48
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.68
Nutlin-3A 1.6μM R06 exp294	3.46

Global Fraction of Cell Lines Where Essential: 83/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	11/28
bone	8/26
breast	1/33
central nervous system	3/56
cervix	0/4
colorectal	3/17
esophagus	2/13
fibroblast	0/1
gastric	0/16
kidney	2/21
liver	1/20
lung	7/75
lymphocyte	6/16
ovary	2/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	3/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	6/29
uterus	0/5

Expression Distribution

Barr body
nuclear heterochromatin
nuclear euchromatin
RNA polymerase II core promoter sequence-specific DNA binding
cellular response to estradiol stimulus
nucleosomal DNA binding
nucleosome
chromatin DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
response to estradiol
nuclear chromatin
protein heterodimerization activity
RNA polymerase II proximal promoter sequence-specific DNA binding
cellular response to lipid
cellular response to organic cyclic compound
cellular response to hormone stimulus
chromatin organization
response to lipid
response to hormone
response to organic cyclic compound
cellular response to oxygen-containing compound
chromosome organization
positive regulation of transcription by RNA polymerase II
cellular response to endogenous stimulus
DNA binding
response to endogenous stimulus
positive regulation of transcription, DNA-templated
response to oxygen-containing compound
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process