SUDS3 [The Human Chemical-Genetic Interaction Map Project]

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======= SUDS3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SUDS3
  * **<color #00a2e8>Official Name</color>**: SDS3 homolog, SIN3A corepressor complex component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64426|64426]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H7L9|Q9H7L9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SUDS3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SUDS3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608250|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:21239494}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sds3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Sin3-type complex|
|Sin3 complex|
|histone deacetylase activity|
|substantia nigra development|
|histone deacetylation|
|protein deacetylation|
|protein deacylation|
|macromolecule deacylation|
|neural nucleus development|
|midbrain development|
|histone deacetylase binding|
|protein deubiquitination|
|nuclear body|
|protein modification by small protein removal|
|enzyme binding|
|histone modification|
|covalent chromatin modification|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|chromatin organization|
|brain development|
|head development|
|negative regulation of transcription by RNA polymerase II|
|apoptotic process|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|programmed cell death|
|chromosome organization|
|cell death|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of cell death|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.06|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.95|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.83|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.82|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.8|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.85|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.07|
|[[:results:exp303|39°C R06 exp303]]|2.51|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ing1|ING1]]|0.568|
|[[:human genes:b:brms1|BRMS1]]|0.528|
|[[:human genes:s:sap130|SAP130]]|0.517|
|[[:human genes:s:sin3a|SIN3A]]|0.492|
|[[:human genes:b:brd1|BRD1]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|1/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2759
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SUDS3 Expression in NALM6 Cells: 6.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>