MKLN1

Entrez Summary: N/A
UniProt Summary: Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1. {ECO:0000250|UniProtKB:O89050}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MK-1775 0.32μM R02 exp75	-3.54
Resveratrol 16μM R03 exp147	-2.39
Sulforaphane 9μM R08 exp526 no dilution day6	-2.16
Dinaciclib 0.007μM R07 exp355	-2.13
Selumetinib 20μM R02 exp81	-2.09
Ribavirin 10μM R01 exp52	-1.97
Torin1 0.08μM R02 exp82	-1.89
Caffeine 2600μM R08 exp463	-1.85
LB-100 4.1μM R02 exp72	-1.85
Bortezomib 0.005μM R00 exp6	-1.81
Hippuristanol 0.12μM R08 exp488	-1.81
TRAIL 5ng/ml R00 exp35	-1.71
Cycloheximide 0.2μM R00 exp15	1.75
WNT3A 44ng/ml R08 exp537	1.76
Oligomycin-A 2μM R00 exp25	1.8
GSK626616 14μM R08 exp485	2.43
Fluvastatin 2.2μM R06 exp282	3.04

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

F5 F8 type C
Muskelin N

regulation of receptor internalization
actin cytoskeleton reorganization
ruffle
regulation of receptor-mediated endocytosis
ubiquitin ligase complex
cell-matrix adhesion
cell cortex
regulation of cell shape
cell-substrate adhesion
regulation of endocytosis
synapse
regulation of cell morphogenesis
actin cytoskeleton organization
cell junction
regulation of vesicle-mediated transport
actin filament-based process
protein homodimerization activity
cell adhesion
biological adhesion
regulation of anatomical structure morphogenesis
cytoskeleton organization
regulation of transport