RBM7

Entrez Summary: N/A
UniProt Summary: Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). Possible involved in germ cell RNA processing and meiosis (Probable). {ECO:0000269|PubMed:27871484, ECO:0000305|PubMed:12634307}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CCT251545 0.2μM R06 exp271	-2.77
Etoposide 1μM R00 exp19	-2.54
Selumetinib 20μM R02 exp81	-2.21
Bleomycin 5μM R08 exp459	-2.02
Vemurafenib 6.6μM R02 exp89	-1.95
Quinacrine 2.5μM R03 exp146	-1.83
Taxol 0.004μM R03 exp103	-1.71
B02 10μM R08 exp453	1.7
Nutlin-3A 1.6μM R06 exp294	1.7
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.71
Trimetrexate 0.03μM R08 exp535	1.71
Benzoate 10000μM R08 exp455	1.74
Bortezomib 0.005μM R00 exp6	1.76
Staurosporine 0.02μM R08 exp524	1.76
Artemisinin 50μM R08 exp450	1.78
Centrinone 0.5μM R07 exp343	1.78
Mubritinib 0.2μM R01 exp48	1.81
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	1.89
Adefovir 20μM R07 exp332	1.89
R-DABN 8μM R03 exp111	1.9
Oligomycin-A 2μM R00 exp25	1.92
Vinblastine 0.015μM R05 exp208	1.97
Phenformin 20μM R03 exp143	1.98
Amiloride 100μM R08 exp447	1.99
RO-3307 4.7μM R02 exp80	1.99
Cytochalasin-B 5μM R07 exp349	2.03
Rucaparib 6.5μM R08 exp520	2.05
Betulinic acid 10 to 15μM on day4 R05 exp222	2.07
Azithromycin 100μM R08 exp452	2.1
Quercetin 20μM R08 exp517	2.1
ML-792 0.2μM R08 exp505	2.15
Hypoxia 5%O2 R04 exp191	2.22
MS023 7μM R03 exp135	2.22
Resveratrol 16μM R03 exp147	2.22
Etoposide 0.1μM R05 exp198	2.24
Rotenone 0.07μM R08 exp431	2.27
Latrunculin-B 10μM R07 exp374	2.31
Nifuroxazide 5μM R03 exp102	2.35
2-Deoxy-D-glucose 800μM R05 exp214	2.45
MKC9989 10μM R03 exp133	2.58
QNZ 0.01μM R08 exp439	2.63
Ethanol 0.01 R05 exp234	2.84
Olaparib 4μM R08 exp512	3.1
Thimerosal 0.85μM R08 exp529	3.66

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

single-stranded RNA binding
regulation of alternative mRNA splicing, via spliceosome
regulation of mRNA splicing, via spliceosome
regulation of RNA splicing
regulation of mRNA processing
meiotic cell cycle
regulation of mRNA metabolic process
nucleolus
cell cycle
RNA binding
reproductive process
reproduction