RBM7 [The Human Chemical-Genetic Interaction Map Project]

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======= RBM7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBM7
  * **<color #00a2e8>Official Name</color>**: RNA binding motif protein 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10179|10179]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y580|Q9Y580]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBM7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBM7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612413|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). Possible involved in germ cell RNA processing and meiosis (Probable). {ECO:0000269|PubMed:27871484, ECO:0000305|PubMed:12634307}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|single-stranded RNA binding|
|regulation of alternative mRNA splicing, via spliceosome|
|regulation of mRNA splicing, via spliceosome|
|regulation of RNA splicing|
|regulation of mRNA processing|
|meiotic cell cycle|
|regulation of mRNA metabolic process|
|nucleolus|
|cell cycle|
|RNA binding|
|reproductive process|
|reproduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.77|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.54|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.21|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-2.02|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.95|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.83|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.71|
|[[:results:exp453|B02 10μM R08 exp453]]|1.7|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.7|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.71|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.71|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.74|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.76|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.76|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.78|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.78|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.81|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.89|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.89|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.9|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.92|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.97|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.98|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.99|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.99|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.03|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.05|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.07|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.1|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.1|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.15|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.22|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.22|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.22|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.24|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.27|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.31|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.35|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.45|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|2.58|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.63|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.84|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.1|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|3.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zcchc8|ZCCHC8]]|0.616|
|[[:human genes:z:zfc3h1|ZFC3H1]]|0.537|
|[[:human genes:v:vezf1|VEZF1]]|0.459|
|[[:human genes:r:rbm41|RBM41]]|0.43|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12688
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBM7 Expression in NALM6 Cells: 4.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>