GGPS1

Entrez Summary: N/A
UniProt Summary: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cerivastatin 0.15μM R05 exp226	-2.65
Selumetinib 20μM R02 exp81	-2.52
Etoposide 0.1μM R05 exp198	-2.48
Rifampicin 1μM R00 exp31	-2.36
Cycloheximide 0.2μM R00 exp15	-2.12
5-Fluorouracil 2μM R00 exp1	-2.11
Epigallocatechin gallate 20μM R05 exp230	-2.05
PF-06409577 20μM R07 exp389	-1.95
Cannabidiol 13μM R08 exp465	-1.93
MLN-4924 0.2μM R00 exp21	-1.92
LY2090314 0.003μM R08 exp499	-1.89
Apcin 50 to 100μM on day4 R04 exp176	-1.88
NFN1 0.1μM R01 exp49	-1.87
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.85
Geldanamycin 0.01μM R05 exp235	-1.83
Doxycycline 10μM R00 exp18	-1.82
Fas-L 44ng/ml R08 exp482	-1.81
Q15 1 to 2μM on day4 R04 exp164	-1.81
Cabazitaxel 0.001μM R05 exp223	-1.78
ABT-702 5μM R07 exp318	-1.76
IU1-C 25μM R04 exp183	-1.76
Sulforaphane 9μM R08 exp525	-1.76
Momordin-Ic 10μM R08 exp506	-1.75
Tubacin 1.6μM R07 exp416	-1.74
Cycloheximide 0.02μM R00 exp14	-1.71
Lead acetate 2000μM R08 exp497	1.72
UM0129480 7μM R02 exp85	1.96
SNS-032 25μM R07 exp401	2.02

Global Fraction of Cell Lines Where Essential: 681/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	26/28
bone	25/26
breast	22/33
central nervous system	56/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	15/16
kidney	19/21
liver	19/20
lung	67/75
lymphocyte	13/16
ovary	22/26
pancreas	24/24
peripheral nervous system	14/16
plasma cell	13/15
prostate	1/1
skin	20/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	3/5

Expression Distribution

geranylgeranyl diphosphate metabolic process
geranylgeranyl diphosphate biosynthetic process
dimethylallyltranstransferase activity
farnesyltranstransferase activity
geranyl diphosphate biosynthetic process
geranyl diphosphate metabolic process
geranyltranstransferase activity
farnesyl diphosphate biosynthetic process
farnesyl diphosphate metabolic process
terpenoid biosynthetic process
isoprenoid biosynthetic process
cholesterol biosynthetic process
regulation of sterol biosynthetic process
secondary alcohol biosynthetic process
regulation of cholesterol biosynthetic process
sterol biosynthetic process
regulation of cholesterol metabolic process
regulation of alcohol biosynthetic process
regulation of steroid biosynthetic process
alcohol biosynthetic process
regulation of steroid metabolic process
cholesterol metabolic process
terpenoid metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
sterol metabolic process
isoprenoid metabolic process
organic hydroxy compound biosynthetic process
regulation of lipid biosynthetic process
phospholipid biosynthetic process
steroid metabolic process
alcohol metabolic process
phospholipid metabolic process
regulation of lipid metabolic process
regulation of small molecule metabolic process
organic hydroxy compound metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
small molecule biosynthetic process
organophosphate metabolic process