GGPS1 [The Human Chemical-Genetic Interaction Map Project]

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======= GGPS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GGPS1
  * **<color #00a2e8>Official Name</color>**: geranylgeranyl diphosphate synthase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9453|9453]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95749|O95749]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GGPS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GGPS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606982|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|polyprenyl synt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|geranylgeranyl diphosphate metabolic process|
|geranylgeranyl diphosphate biosynthetic process|
|dimethylallyltranstransferase activity|
|farnesyltranstransferase activity|
|geranyl diphosphate biosynthetic process|
|geranyl diphosphate metabolic process|
|geranyltranstransferase activity|
|farnesyl diphosphate biosynthetic process|
|farnesyl diphosphate metabolic process|
|terpenoid biosynthetic process|
|isoprenoid biosynthetic process|
|cholesterol biosynthetic process|
|regulation of sterol biosynthetic process|
|secondary alcohol biosynthetic process|
|regulation of cholesterol biosynthetic process|
|sterol biosynthetic process|
|regulation of cholesterol metabolic process|
|regulation of alcohol biosynthetic process|
|regulation of steroid biosynthetic process|
|alcohol biosynthetic process|
|regulation of steroid metabolic process|
|cholesterol metabolic process|
|terpenoid metabolic process|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|sterol metabolic process|
|isoprenoid metabolic process|
|organic hydroxy compound biosynthetic process|
|regulation of lipid biosynthetic process|
|phospholipid biosynthetic process|
|steroid metabolic process|
|alcohol metabolic process|
|phospholipid metabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|organic hydroxy compound metabolic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|identical protein binding|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.65|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.52|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.48|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-2.36|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-2.12|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.11|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.05|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.95|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.93|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.92|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.89|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.88|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.87|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.85|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.83|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.82|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-1.81|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.81|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.78|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-1.76|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.76|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.76|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.75|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.74|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.71|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.72|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.96|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rabggtb|RABGGTB]]|0.547|
|[[:human genes:h:hars|HARS]]|0.539|
|[[:human genes:g:gemin8|GEMIN8]]|0.479|
|[[:human genes:g:gemin6|GEMIN6]]|0.462|
|[[:human genes:n:nsmce1|NSMCE1]]|0.454|
|[[:human genes:s:srp14|SRP14]]|0.421|
|[[:human genes:u:utp23|UTP23]]|0.417|
|[[:human genes:t:ten1|TEN1]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 681/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|26/28|
|bone|25/26|
|breast|22/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|19/21|
|liver|19/20|
|lung|67/75|
|lymphocyte|13/16|
|ovary|22/26|
|pancreas|24/24|
|peripheral nervous system|14/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|20/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 979
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GGPS1 Expression in NALM6 Cells: 4.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>