FGFR1
Gene Information
- Official Symbol: FGFR1
- Official Name: fibroblast growth factor receptor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2260
- UniProt: P11362
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pkinase |
| Pkinase Tyr |
| ig |
| I-set |
GO Terms
| positive regulation of parathyroid hormone secretion |
| positive regulation of mitotic cell cycle DNA replication |
| fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development |
| regulation of parathyroid hormone secretion |
| regulation of lateral mesodermal cell fate specification |
| negative regulation of fibroblast growth factor production |
| ventricular zone neuroblast division |
| regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling |
| receptor-receptor interaction |
| regulation of mitotic cell cycle DNA replication |
| orbitofrontal cortex development |
| positive regulation of endothelial cell chemotaxis to fibroblast growth factor |
| positive regulation of cell chemotaxis to fibroblast growth factor |
| vitamin D3 metabolic process |
| positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway |
| fibroblast growth factor-activated receptor activity |
| forebrain ventricular zone progenitor cell division |
| regulation of mesodermal cell differentiation |
| regulation of endothelial cell chemotaxis to fibroblast growth factor |
| regulation of cell chemotaxis to fibroblast growth factor |
| positive regulation of nuclear cell cycle DNA replication |
| regulation of mesodermal cell fate specification |
| regulation of mesoderm formation |
| regulation of fibroblast growth factor production |
| regulation of phosphate transport |
| lung-associated mesenchyme development |
| mesenchymal-epithelial cell signaling |
| forebrain neuroblast division |
| outer ear morphogenesis |
| regulation of branching involved in salivary gland morphogenesis |
| positive regulation of DNA-dependent DNA replication |
| regulation of cell fate specification |
| positive regulation of vascular endothelial cell proliferation |
| neuroblast division |
| positive regulation of endothelial cell chemotaxis |
| organ induction |
| vitamin D metabolic process |
| neuronal stem cell division |
| regulation of nuclear cell cycle DNA replication |
| branching involved in salivary gland morphogenesis |
| regulation of mesoderm development |
| paraxial mesoderm development |
| auditory receptor cell development |
| regulation of vascular endothelial cell proliferation |
| middle ear morphogenesis |
| regulation of endothelial cell chemotaxis |
| somatic stem cell division |
| fibroblast growth factor binding |
| positive regulation of cardiac muscle cell proliferation |
| positive regulation of mesenchymal cell proliferation |
| inner ear auditory receptor cell differentiation |
| developmental induction |
| cell proliferation in forebrain |
| regulation of cell fate commitment |
| salivary gland morphogenesis |
| neuroblast proliferation |
| salivary gland development |
| regulation of mesenchymal cell proliferation |
| positive regulation of cardiac muscle tissue growth |
| stem cell division |
| hair cell differentiation |
| SH2 domain binding |
| positive regulation of DNA replication |
| fat-soluble vitamin metabolic process |
| regulation of animal organ formation |
| regulation of gastrulation |
| positive regulation of heart growth |
| regulation of cardiac muscle cell proliferation |
| inner ear receptor cell development |
| positive regulation of phospholipase C activity |
| exocrine system development |
| positive regulation of cardiac muscle tissue development |
| neuroepithelial cell differentiation |
| regulation of endocrine process |
| regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| regulation of phospholipase C activity |
| positive regulation of organ growth |
| columnar/cuboidal epithelial cell development |
| inner ear receptor cell differentiation |
| stem cell proliferation |
| regulation of DNA-dependent DNA replication |
| transmembrane receptor protein tyrosine kinase activity |
| positive regulation of blood vessel endothelial cell migration |
| regulation of morphogenesis of a branching structure |
| mechanoreceptor differentiation |
| regulation of cardiac muscle tissue growth |
| positive regulation of phospholipase activity |
| regulation of heart growth |
| forebrain generation of neurons |
| positive regulation of striated muscle tissue development |
| positive regulation of muscle organ development |
| positive regulation of muscle tissue development |
| phosphatidylinositol-mediated signaling |
| positive regulation of lipase activity |
| regulation of phospholipase activity |
| neural precursor cell proliferation |
| inositol lipid-mediated signaling |
| regulation of cardiac muscle tissue development |
| fibroblast growth factor receptor signaling pathway |
| positive regulation of animal organ morphogenesis |
| chondrocyte differentiation |
| midbrain development |
| positive regulation of phosphatidylinositol 3-kinase signaling |
| ureteric bud development |
| mesonephric tubule development |
| mesonephric epithelium development |
| protein tyrosine kinase activity |
| regulation of blood vessel endothelial cell migration |
| mesonephros development |
| positive regulation of endothelial cell proliferation |
| regulation of organ growth |
| regulation of anion transport |
| columnar/cuboidal epithelial cell differentiation |
| regulation of lipase activity |
| inner ear morphogenesis |
| gland morphogenesis |
| positive regulation of endothelial cell migration |
| regulation of DNA replication |
| cellular response to fibroblast growth factor stimulus |
| limbic system development |
| response to fibroblast growth factor |
| ear morphogenesis |
| neuron migration |
| regulation of phosphatidylinositol 3-kinase signaling |
| mesoderm development |
| vitamin metabolic process |
| embryonic appendage morphogenesis |
| embryonic limb morphogenesis |
| positive regulation of hormone secretion |
| secondary alcohol metabolic process |
| regulation of embryonic development |
| kidney epithelium development |
| regulation of endothelial cell proliferation |
| regulation of striated muscle tissue development |
| regulation of muscle tissue development |
| positive regulation of chemotaxis |
| regulation of muscle organ development |
| positive regulation of epithelial cell migration |
| peptidyl-tyrosine phosphorylation |
| sensory perception of sound |
| peptidyl-tyrosine modification |
| limb morphogenesis |
| appendage morphogenesis |
| cytokine production |
| positive regulation of mitotic cell cycle |
| regulation of extrinsic apoptotic signaling pathway |
| mesenchymal cell differentiation |
| cell maturation |
| regulation of endothelial cell migration |
| morphogenesis of a branching epithelium |
| positive regulation of protein kinase B signaling |
| sensory perception of mechanical stimulus |
| morphogenesis of a branching structure |
| lung development |
| heparin binding |
| positive regulation of developmental growth |
| cartilage development |
| respiratory tube development |
| limb development |
| regulation of morphogenesis of an epithelium |
| appendage development |
| positive regulation of epithelial cell proliferation |
| epithelial cell development |
| protein autophosphorylation |
| inner ear development |
| respiratory system development |
| hormone metabolic process |
| receptor complex |
| regulation of chemotaxis |
| regulation of protein kinase B signaling |
| regulation of epithelial cell migration |
| ear development |
| mesenchyme development |
| connective tissue development |
| skeletal system morphogenesis |
| developmental maturation |
| cytoplasmic vesicle |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| positive regulation of growth |
| steroid metabolic process |
| positive regulation of MAP kinase activity |
| regulation of hormone secretion |
| kidney development |
| regulation of cellular response to growth factor stimulus |
| negative regulation of cytokine production |
| positive regulation of neuron projection development |
| renal system development |
| positive regulation of cell cycle process |
| embryonic organ morphogenesis |
| epidermal cell differentiation |
| alcohol metabolic process |
| angiogenesis |
| urogenital system development |
| regulation of developmental growth |
| regulation of epithelial cell proliferation |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| positive regulation of neuron differentiation |
| MAPK cascade |
| in utero embryonic development |
| positive regulation of cell cycle |
| positive regulation of cell projection organization |
| forebrain development |
| signal transduction by protein phosphorylation |
| regulation of apoptotic signaling pathway |
| positive regulation of secretion by cell |
| blood vessel morphogenesis |
| gland development |
| epidermis development |
| morphogenesis of an epithelium |
| embryonic organ development |
| positive regulation of secretion |
| organic hydroxy compound metabolic process |
| positive regulation of neurogenesis |
| blood vessel development |
| cell division |
| skeletal system development |
| regulation of neuron projection development |
| positive regulation of cell migration |
| cellular response to growth factor stimulus |
| vasculature development |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of protein serine/threonine kinase activity |
| cardiovascular system development |
| positive regulation of cell motility |
| response to growth factor |
| positive regulation of protein kinase activity |
| regulation of hormone levels |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| sensory organ development |
| positive regulation of locomotion |
| cell population proliferation |
| tissue morphogenesis |
| embryonic morphogenesis |
| positive regulation of kinase activity |
| regulation of system process |
| positive regulation of response to external stimulus |
| regulation of mitotic cell cycle |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| regulation of neuron differentiation |
| positive regulation of transferase activity |
| regulation of growth |
| epithelial cell differentiation |
| regulation of cytokine production |
| regulation of plasma membrane bounded cell projection organization |
| regulation of ion transport |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| brain development |
| regulation of secretion by cell |
| regulation of cell cycle process |
| regulation of MAPK cascade |
| positive regulation of hydrolase activity |
| head development |
| regulation of protein kinase activity |
| regulation of secretion |
| neuron development |
| regulation of neurogenesis |
| tube development |
| regulation of cell migration |
| nucleolus |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| regulation of kinase activity |
| protein homodimerization activity |
| peptidyl-amino acid modification |
| anatomical structure formation involved in morphogenesis |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| regulation of cell development |
| animal organ morphogenesis |
| cell migration |
| positive regulation of cell differentiation |
| sensory perception |
| protein phosphorylation |
| regulation of transferase activity |
| embryo development |
| central nervous system development |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| epithelium development |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| regulation of hydrolase activity |
| phosphorylation |
| locomotion |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| nervous system process |
| negative regulation of cellular macromolecule biosynthetic process |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| ATP binding |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| UM0130462 0.025 to 0.035μM day4 R05 exp247 | -2.11 |
| QNZ 0.01μM R08 exp439 | -1.84 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 15/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 3/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 3/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17172
- Expression level (log2 read counts): 6.27
Expression Distribution
FGFR1 Expression in NALM6 Cells: 6.27
