S100A5

Entrez Summary: N/A
UniProt Summary: Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites. {ECO:0000269|PubMed:10882717}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM0130462 0.025 to 0.035μM day4 R05 exp247	-2.12
CFI-400945 25μM R08 exp469	-1.76
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-1.74
HMS-I2 1μM R06 exp286	1.73
IU1-C 25μM R04 exp183	1.84
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.95

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

copper ion binding
neuronal cell body
calcium ion binding
zinc ion binding
protein homodimerization activity