COL4A2

Entrez Summary: This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008].
UniProt Summary: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nicotinamide 2000μM R01 exp50	1.91
Taxol 0.002μM R01 exp54	2.25

C4
Collagen

collagen type IV trimer
collagen-activated tyrosine kinase receptor signaling pathway
collagen-activated signaling pathway
extracellular matrix structural constituent conferring tensile strength
endodermal cell differentiation
endoderm formation
response to activity
endoderm development
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
formation of primary germ layer
negative regulation of vasculature development
extracellular matrix structural constituent
cellular response to transforming growth factor beta stimulus
gastrulation
response to transforming growth factor beta
extracellular matrix
aging
regulation of angiogenesis
endoplasmic reticulum lumen
angiogenesis
regulation of vasculature development
extracellular matrix organization
collagen-containing extracellular matrix
extracellular structure organization
blood vessel morphogenesis
blood vessel development
cellular response to growth factor stimulus
vasculature development
transmembrane receptor protein tyrosine kinase signaling pathway
cardiovascular system development
response to growth factor
embryonic morphogenesis
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
tube morphogenesis
enzyme linked receptor protein signaling pathway
tube development
circulatory system development