COL4A2 [The Human Chemical-Genetic Interaction Map Project]

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======= COL4A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COL4A2
  * **<color #00a2e8>Official Name</color>**: collagen type IV alpha 2 chain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1284|1284]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08572|P08572]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COL4A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COL4A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120090|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C4|
|Collagen|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|collagen type IV trimer|
|collagen-activated tyrosine kinase receptor signaling pathway|
|collagen-activated signaling pathway|
|extracellular matrix structural constituent conferring tensile strength|
|endodermal cell differentiation|
|endoderm formation|
|response to activity|
|endoderm development|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|formation of primary germ layer|
|negative regulation of vasculature development|
|extracellular matrix structural constituent|
|cellular response to transforming growth factor beta stimulus|
|gastrulation|
|response to transforming growth factor beta|
|extracellular matrix|
|aging|
|regulation of angiogenesis|
|endoplasmic reticulum lumen|
|angiogenesis|
|regulation of vasculature development|
|extracellular matrix organization|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|blood vessel morphogenesis|
|blood vessel development|
|cellular response to growth factor stimulus|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cardiovascular system development|
|response to growth factor|
|embryonic morphogenesis|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|tube morphogenesis|
|enzyme linked receptor protein signaling pathway|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|embryo development|
|regulation of anatomical structure morphogenesis|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|response to endogenous stimulus|
|extracellular space|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|tissue development|
|macromolecule biosynthetic process|
|extracellular region|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.91|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.435|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.427|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2221
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COL4A2 Expression in NALM6 Cells: -0.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>