ABT1

Gene Information

Official Symbol: ABT1
Official Name: activator of basal transcription 1
Aliases and Previous Symbols: N/A
Entrez ID: 29777
UniProt: Q9ULW3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
PSMD11	0.446
TFIP11	0.441
DTL	0.439
TCEB3C	0.422
WDR87	0.422
VASN	0.418
ORC1	0.418
TCEB3CL2	0.417
ORC6	0.416
C14orf93	0.415
TBC1D3H	0.406
CHMP2A	0.403
LRR1	0.401
PAN2	0.4

Global Fraction of Cell Lines Where Essential: 8/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1207
Expression level (log2 read counts): 4.96

Expression Distribution

Screen	Score
HMS-I1 1μM R01 exp46	1.8
CHIR-124 0.04μM R06 exp272	1.85
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	1.87
Pyronaridine 1μM R06 exp295	1.94

small-subunit processome assembly
endonucleolytic cleavage to generate mature 5-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
rRNA 5-end processing
endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
endonucleolytic cleavage involved in rRNA processing
endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ncRNA 5-end processing
ribosomal small subunit assembly
RNA 5-end processing
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
cleavage involved in rRNA processing
maturation of 5.8S rRNA
spinal cord motor neuron differentiation
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
maturation of SSU-rRNA
ventral spinal cord development
cell differentiation in spinal cord
ribosome assembly
ribosomal small subunit biogenesis
RNA phosphodiester bond hydrolysis, endonucleolytic
spinal cord development
RNA phosphodiester bond hydrolysis
central nervous system neuron differentiation
transcription factor complex
rRNA processing
rRNA metabolic process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
transcription coactivator activity
nucleic acid phosphodiester bond hydrolysis
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
organelle assembly