ZFAND5 [The Human Chemical-Genetic Interaction Map Project]

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======= ZFAND5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZFAND5
  * **<color #00a2e8>Official Name</color>**: zinc finger AN1-type containing 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7763|7763]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O76080|O76080]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZFAND5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZFAND5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604761|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in protein degradation via the ubiquitin- proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4- induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. {ECO:0000269|PubMed:14754897}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-A20|
|zf-AN1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular component|
|molecular function|
|zinc ion binding|
|DNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-2.97|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.64|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.43|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.41|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.41|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.41|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.41|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.39|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-2.33|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2.32|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.28|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.27|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.26|
|[[:results:exp135|MS023 7μM R03 exp135]]|-2.19|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-2.19|
|[[:results:exp539|42°C R08 exp539]]|-2.11|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.1|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.09|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.03|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-2.02|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-2.02|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-2.01|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.98|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.97|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.93|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.93|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.9|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.87|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.86|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.84|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.72|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.72|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.72|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.74|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.74|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.87|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.97|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|2.19|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:smg7|SMG7]]|0.677|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.65|
|[[:human genes:a:atp13a1|ATP13A1]]|0.612|
|[[:human genes:p:psmc2|PSMC2]]|0.608|
|[[:human genes:s:smg1|SMG1]]|0.599|
|[[:human genes:p:psmd1|PSMD1]]|0.591|
|[[:human genes:p:psmc1|PSMC1]]|0.569|
|[[:human genes:m:myo1h|MYO1H]]|0.564|
|[[:human genes:p:psma6|PSMA6]]|0.559|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.558|
|[[:human genes:s:ssh2|SSH2]]|0.549|
|[[:human genes:p:psmd11|PSMD11]]|0.548|
|[[:human genes:c:chd4|CHD4]]|0.546|
|[[:human genes:m:mdm2|MDM2]]|0.543|
|[[:human genes:v:vasn|VASN]]|0.542|
|[[:human genes:s:supt6h|SUPT6H]]|0.542|
|[[:human genes:p:pan3|PAN3]]|0.541|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.54|
|[[:human genes:d:ddtl|DDTL]]|0.539|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.526|
|[[:human genes:p:psmc6|PSMC6]]|0.519|
|[[:human genes:s:scaf1|SCAF1]]|0.512|
|[[:human genes:r:rps28|RPS28]]|0.51|
|[[:human genes:s:smg5|SMG5]]|0.51|
|[[:human genes:r:rnpc3|RNPC3]]|0.507|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.503|
|[[:human genes:p:psmd14|PSMD14]]|0.503|
|[[:human genes:p:psmb4|PSMB4]]|0.503|
|[[:human genes:p:pan2|PAN2]]|0.503|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.503|
|[[:human genes:n:nupl1|NUPL1]]|0.502|
|[[:human genes:c:cdk12|CDK12]]|0.502|
|[[:human genes:p:psmd2|PSMD2]]|0.501|
|[[:human genes:z:znf106|ZNF106]]|0.498|
|[[:human genes:t:twistnb|TWISTNB]]|0.497|
|[[:human genes:a:ankle2|ANKLE2]]|0.496|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.496|
|[[:human genes:c:cdc73|CDC73]]|0.495|
|[[:human genes:h:hap1|HAP1]]|0.495|
|[[:human genes:r:ranbp2|RANBP2]]|0.495|
|[[:human genes:r:rad51|RAD51]]|0.492|
|[[:human genes:d:dtl|DTL]]|0.489|
|[[:human genes:l:lad1|LAD1]]|0.488|
|[[:human genes:n:nop16|NOP16]]|0.487|
|[[:human genes:r:rpl30|RPL30]]|0.486|
|[[:human genes:m:med17|MED17]]|0.485|
|[[:human genes:e:exosc9|EXOSC9]]|0.485|
|[[:human genes:n:nup85|NUP85]]|0.484|
|[[:human genes:u:upf1|UPF1]]|0.483|
|[[:human genes:p:psmc4|PSMC4]]|0.483|
|[[:human genes:p:paf1|PAF1]]|0.482|
|[[:human genes:r:rnf4|RNF4]]|0.482|
|[[:human genes:c:cdca3|CDCA3]]|0.481|
|[[:human genes:c:ccna2|CCNA2]]|0.481|
|[[:human genes:s:slc38a7|SLC38A7]]|0.48|
|[[:human genes:s:slc6a17|SLC6A17]]|0.478|
|[[:human genes:c:cbwd3|CBWD3]]|0.477|
|[[:human genes:a:ankle1|ANKLE1]]|0.477|
|[[:human genes:p:pola2|POLA2]]|0.477|
|[[:human genes:r:rps12|RPS12]]|0.475|
|[[:human genes:s:slc4a1|SLC4A1]]|0.474|
|[[:human genes:w:wdr43|WDR43]]|0.474|
|[[:human genes:z:znf830|ZNF830]]|0.474|
|[[:human genes:p:psmb3|PSMB3]]|0.472|
|[[:human genes:r:rpl35|RPL35]]|0.472|
|[[:human genes:m:mbtd1|MBTD1]]|0.472|
|[[:human genes:c:c14orf93|C14orf93]]|0.471|
|[[:human genes:d:dnm2|DNM2]]|0.471|
|[[:human genes:c:cdt1|CDT1]]|0.469|
|[[:human genes:p:psmd3|PSMD3]]|0.468|
|[[:human genes:t:terf2|TERF2]]|0.468|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.468|
|[[:human genes:s:sel1l|SEL1L]]|0.468|
|[[:human genes:p:psmd6|PSMD6]]|0.468|
|[[:human genes:r:rrn3|RRN3]]|0.467|
|[[:human genes:p:psma7|PSMA7]]|0.465|
|[[:human genes:p:plcg2|PLCG2]]|0.465|
|[[:human genes:r:rnf121|RNF121]]|0.465|
|[[:human genes:a:adrm1|ADRM1]]|0.464|
|[[:human genes:n:nbpf10|NBPF10]]|0.463|
|[[:human genes:r:rpl14|RPL14]]|0.463|
|[[:human genes:a:akirin2|AKIRIN2]]|0.462|
|[[:human genes:t:tceb3c|TCEB3C]]|0.462|
|[[:human genes:c:chmp2a|CHMP2A]]|0.461|
|[[:human genes:a:ahctf1|AHCTF1]]|0.461|
|[[:human genes:r:rbm39|RBM39]]|0.458|
|[[:human genes:p:polr2j3|POLR2J3]]|0.458|
|[[:human genes:c:cactin|CACTIN]]|0.457|
|[[:human genes:i:ik|IK]]|0.457|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.457|
|[[:human genes:p:psmb1|PSMB1]]|0.457|
|[[:human genes:c:cdc45|CDC45]]|0.456|
|[[:human genes:d:disp2|DISP2]]|0.455|
|[[:human genes:k:kpnb1|KPNB1]]|0.455|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.455|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.455|
|[[:human genes:m:mt1e|MT1E]]|0.455|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.455|
|[[:human genes:r:rps2|RPS2]]|0.455|
|[[:human genes:o:ogfr|OGFR]]|0.455|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.455|
|[[:human genes:p:psma1|PSMA1]]|0.454|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.454|
|[[:human genes:c:cbwd5|CBWD5]]|0.453|
|[[:human genes:p:polr2d|POLR2D]]|0.453|
|[[:human genes:t:traip|TRAIP]]|0.453|
|[[:human genes:d:dhx9|DHX9]]|0.453|
|[[:human genes:c:chchd3|CHCHD3]]|0.451|
|[[:human genes:m:med14|MED14]]|0.45|
|[[:human genes:a:arcn1|ARCN1]]|0.45|
|[[:human genes:p:psmb2|PSMB2]]|0.449|
|[[:human genes:c:copa|COPA]]|0.449|
|[[:human genes:f:fam86b2|FAM86B2]]|0.448|
|[[:human genes:r:rad21|RAD21]]|0.448|
|[[:human genes:a:aaas|AAAS]]|0.447|
|[[:human genes:p:psmd13|PSMD13]]|0.446|
|[[:human genes:r:rps9|RPS9]]|0.445|
|[[:human genes:c:chmp4b|CHMP4B]]|0.444|
|[[:human genes:n:nbpf16|NBPF16]]|0.443|
|[[:human genes:p:psmc3|PSMC3]]|0.443|
|[[:human genes:s:syt9|SYT9]]|0.442|
|[[:human genes:a:atxn1|ATXN1]]|0.439|
|[[:human genes:p:pole|POLE]]|0.439|
|[[:human genes:s:setd1a|SETD1A]]|0.439|
|[[:human genes:m:mtch2|MTCH2]]|0.439|
|[[:human genes:m:myh7b|MYH7B]]|0.439|
|[[:human genes:a:acbd4|ACBD4]]|0.438|
|[[:human genes:p:pcf11|PCF11]]|0.437|
|[[:human genes:h:hivep3|HIVEP3]]|0.437|
|[[:human genes:f:fbxo5|FBXO5]]|0.437|
|[[:human genes:c:col2a1|COL2A1]]|0.436|
|[[:human genes:c:cope|COPE]]|0.436|
|[[:human genes:r:rps3|RPS3]]|0.435|
|[[:human genes:p:psmd7|PSMD7]]|0.435|
|[[:human genes:p:prpf8|PRPF8]]|0.434|
|[[:human genes:n:narfl|NARFL]]|0.434|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.434|
|[[:human genes:p:pwp2|PWP2]]|0.434|
|[[:human genes:t:ticrr|TICRR]]|0.433|
|[[:human genes:r:rbbp5|RBBP5]]|0.433|
|[[:human genes:u:ubxn4|UBXN4]]|0.432|
|[[:human genes:r:rpl38|RPL38]]|0.432|
|[[:human genes:i:iscu|ISCU]]|0.431|
|[[:human genes:d:dock6|DOCK6]]|0.43|
|[[:human genes:r:rpsa|RPSA]]|0.43|
|[[:human genes:r:rpl34|RPL34]]|0.43|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.43|
|[[:human genes:k:kctd17|KCTD17]]|0.429|
|[[:human genes:g:golga8o|GOLGA8O]]|0.429|
|[[:human genes:r:rnf113a|RNF113A]]|0.429|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.429|
|[[:human genes:o:orc6|ORC6]]|0.429|
|[[:human genes:r:rpl6|RPL6]]|0.429|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.428|
|[[:human genes:s:sult2b1|SULT2B1]]|0.428|
|[[:human genes:u:upf2|UPF2]]|0.428|
|[[:human genes:f:fbxw9|FBXW9]]|0.428|
|[[:human genes:t:terf1|TERF1]]|0.428|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.428|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.427|
|[[:human genes:c:cbwd6|CBWD6]]|0.427|
|[[:human genes:c:cnot1|CNOT1]]|0.427|
|[[:human genes:a:aqr|AQR]]|0.426|
|[[:human genes:n:napa|NAPA]]|0.425|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.424|
|[[:human genes:a:acsf2|ACSF2]]|0.424|
|[[:human genes:c:c19orf53|C19orf53]]|0.424|
|[[:human genes:e:exosc5|EXOSC5]]|0.424|
|[[:human genes:c:copg1|COPG1]]|0.424|
|[[:human genes:s:sec13|SEC13]]|0.424|
|[[:human genes:l:lrr1|LRR1]]|0.424|
|[[:human genes:m:mki67ip|MKI67IP]]|0.423|
|[[:human genes:k:krt78|KRT78]]|0.422|
|[[:human genes:c:ckap5|CKAP5]]|0.421|
|[[:human genes:k:klhl12|KLHL12]]|0.42|
|[[:human genes:r:rrp15|RRP15]]|0.42|
|[[:human genes:s:supt5h|SUPT5H]]|0.419|
|[[:human genes:m:mms22l|MMS22L]]|0.418|
|[[:human genes:s:smg6|SMG6]]|0.418|
|[[:human genes:n:nsf|NSF]]|0.418|
|[[:human genes:m:morc2|MORC2]]|0.417|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.416|
|[[:human genes:c:copb1|COPB1]]|0.416|
|[[:human genes:r:rps14|RPS14]]|0.415|
|[[:human genes:i:igfn1|IGFN1]]|0.415|
|[[:human genes:u:ube4a|UBE4A]]|0.415|
|[[:human genes:m:mul1|MUL1]]|0.415|
|[[:human genes:c:ccdc94|CCDC94]]|0.415|
|[[:human genes:n:nup153|NUP153]]|0.415|
|[[:human genes:t:ttc1|TTC1]]|0.415|
|[[:human genes:t:tra2b|TRA2B]]|0.414|
|[[:human genes:d:ddt|DDT]]|0.414|
|[[:human genes:n:nup188|NUP188]]|0.414|
|[[:human genes:r:rpa2|RPA2]]|0.413|
|[[:human genes:c:ccdc116|CCDC116]]|0.412|
|[[:human genes:u:ubl5|UBL5]]|0.412|
|[[:human genes:n:nol12|NOL12]]|0.412|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.412|
|[[:human genes:n:nup205|NUP205]]|0.412|
|[[:human genes:n:nup43|NUP43]]|0.411|
|[[:human genes:n:naaladl1|NAALADL1]]|0.411|
|[[:human genes:r:rsl1d1|RSL1D1]]|0.41|
|[[:human genes:s:snip1|SNIP1]]|0.41|
|[[:human genes:n:ndc1|NDC1]]|0.409|
|[[:human genes:c:clpx|CLPX]]|0.409|
|[[:human genes:r:rfpl3|RFPL3]]|0.408|
|[[:human genes:a:arid2|ARID2]]|0.408|
|[[:human genes:n:nol10|NOL10]]|0.407|
|[[:human genes:n:nup54|NUP54]]|0.407|
|[[:human genes:b:bcl2l2|BCL2L2]]|0.407|
|[[:human genes:m:med12|MED12]]|0.406|
|[[:human genes:s:s1pr4|S1PR4]]|0.406|
|[[:human genes:d:ddx56|DDX56]]|0.406|
|[[:human genes:c:ctr9|CTR9]]|0.406|
|[[:human genes:n:nup133|NUP133]]|0.406|
|[[:human genes:c:cox8a|COX8A]]|0.406|
|[[:human genes:d:dync1i2|DYNC1I2]]|0.406|
|[[:human genes:a:aamp|AAMP]]|0.406|
|[[:human genes:m:map7d1|MAP7D1]]|0.405|
|[[:human genes:c:chaf1a|CHAF1A]]|0.404|
|[[:human genes:r:rps20|RPS20]]|0.403|
|[[:human genes:d:dhx38|DHX38]]|0.403|
|[[:human genes:t:tfip11|TFIP11]]|0.402|
|[[:human genes:c:cacna1a|CACNA1A]]|0.402|
|[[:human genes:r:ran|RAN]]|0.401|
|[[:human genes:d:ddx21|DDX21]]|0.401|
|[[:human genes:o:orc1|ORC1]]|0.4|
|[[:human genes:e:egr2|EGR2]]|0.4|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.4|
|[[:human genes:t:top1mt|TOP1MT]]|0.4|
|[[:human genes:b:bod1l1|BOD1L1]]|0.4|
|[[:human genes:z:znf655|ZNF655]]|0.4|
|[[:human genes:r:rfc1|RFC1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1400
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZFAND5 Expression in NALM6 Cells: 6.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>