RPS6KA6

Gene Information

Official Symbol: RPS6KA6
Official Name: ribosomal protein S6 kinase A6
Aliases and Previous Symbols: N/A
Entrez ID: 27330
UniProt: Q9UK32
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010].
UniProt Summary: Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16074
Expression level (log2 read counts): 2.95

Expression Distribution

Screen	Score
Thalidomide 20μM R07 exp406	-2.14
Fas-L 44ng/ml R08 exp482	1.9
Lead acetate 990μM R08 exp496	2
Docetaxel 0.002μM R01 exp45	2.04

Pkinase Tyr
Pkinase C
Pkinase

ribosomal protein S6 kinase activity
negative regulation of mesoderm development
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
DNA damage response, signal transduction resulting in transcription
regulation of mesoderm development
negative regulation of embryonic development
negative regulation of ERK1 and ERK2 cascade
DNA damage response, signal transduction by p53 class mediator
signal transduction in response to DNA damage
signal transduction by p53 class mediator
regulation of embryonic development
fibrillar center
negative regulation of MAPK cascade
magnesium ion binding
protein kinase activity
regulation of ERK1 and ERK2 cascade
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
regulation of MAPK cascade
cellular response to DNA damage stimulus
nucleolus
negative regulation of developmental process
protein phosphorylation
central nervous system development
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of multicellular organismal process
mitochondrion
negative regulation of signal transduction
phosphorylation
negative regulation of cell communication
negative regulation of signaling
regulation of protein phosphorylation
ATP binding
regulation of phosphorylation
negative regulation of response to stimulus