PLA2G1B
Gene Information
- Official Symbol: PLA2G1B
- Official Name: phospholipase A2 group IB
- Aliases and Previous Symbols: N/A
- Entrez ID: 5319
- UniProt: P04054
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. {ECO:0000269|PubMed:19297324}.
Pfam Domains GO Terms
Pfam Domains
| Phospholip A2 1 |
GO Terms
| activation of phospholipase A2 activity |
| positive regulation of phospholipase A2 activity |
| bile acid binding |
| interleukin-8 production |
| regulation of phospholipase A2 activity |
| calcium-dependent phospholipase A2 activity |
| phosphatidylinositol acyl-chain remodeling |
| phosphatidylglycerol acyl-chain remodeling |
| innate immune response in mucosa |
| leukotriene biosynthetic process |
| phosphatidylserine acyl-chain remodeling |
| arachidonate transport |
| arachidonic acid secretion |
| phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) |
| phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) |
| phosphatidylethanolamine acyl-chain remodeling |
| phosphatidylcholine acyl-chain remodeling |
| icosanoid secretion |
| phospholipase A2 activity |
| mucosal immune response |
| phosphatidylglycerol metabolic process |
| phosphatidylserine metabolic process |
| icosanoid transport |
| fatty acid derivative transport |
| leukotriene metabolic process |
| organ or tissue specific immune response |
| antibacterial humoral response |
| phosphatidic acid biosynthetic process |
| phosphatidic acid metabolic process |
| icosanoid biosynthetic process |
| positive regulation of fibroblast proliferation |
| positive regulation of calcium ion transport into cytosol |
| regulation of glucose import |
| long-chain fatty acid transport |
| positive regulation of phospholipase activity |
| antimicrobial humoral immune response mediated by antimicrobial peptide |
| positive regulation of lipase activity |
| regulation of phospholipase activity |
| fatty acid transport |
| regulation of glucose transmembrane transport |
| phosphatidylcholine metabolic process |
| acid secretion |
| regulation of fibroblast proliferation |
| neutrophil chemotaxis |
| secretory granule |
| granulocyte chemotaxis |
| fatty acid derivative biosynthetic process |
| neutrophil migration |
| defense response to Gram-positive bacterium |
| regulation of lipase activity |
| regulation of calcium ion transport into cytosol |
| granulocyte migration |
| phospholipid binding |
| antimicrobial humoral response |
| icosanoid metabolic process |
| fatty acid biosynthetic process |
| positive regulation of calcium ion transport |
| myeloid leukocyte migration |
| monocarboxylic acid transport |
| leukocyte chemotaxis |
| cytokine production |
| positive regulation of NF-kappaB transcription factor activity |
| activation of MAPK activity |
| cellular response to insulin stimulus |
| fatty acid derivative metabolic process |
| phosphatidylinositol metabolic process |
| monocarboxylic acid biosynthetic process |
| ammonium ion metabolic process |
| cellular modified amino acid metabolic process |
| glycerophospholipid biosynthetic process |
| cell chemotaxis |
| glycerolipid biosynthetic process |
| response to insulin |
| actin filament organization |
| phospholipid biosynthetic process |
| regulation of calcium ion transport |
| positive regulation of DNA-binding transcription factor activity |
| positive regulation of MAP kinase activity |
| cellular response to peptide hormone stimulus |
| positive regulation of protein secretion |
| positive regulation of ion transport |
| positive regulation of cytosolic calcium ion concentration |
| positive regulation of peptide secretion |
| carboxylic acid transport |
| organic acid transport |
| lipid transport |
| lipid catabolic process |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| glycerophospholipid metabolic process |
| lipid localization |
| fatty acid metabolic process |
| cellular response to peptide |
| regulation of cytosolic calcium ion concentration |
| activation of protein kinase activity |
| defense response to bacterium |
| signaling receptor binding |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| humoral immune response |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| leukocyte migration |
| regulation of metal ion transport |
| response to peptide hormone |
| positive regulation of secretion by cell |
| positive regulation of protein transport |
| regulation of DNA-binding transcription factor activity |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| supramolecular fiber organization |
| organic anion transport |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| cellular divalent inorganic cation homeostasis |
| response to peptide |
| divalent inorganic cation homeostasis |
| actin cytoskeleton organization |
| regulation of peptide secretion |
| neutrophil mediated immunity |
| regulation of protein serine/threonine kinase activity |
| myeloid leukocyte mediated immunity |
| monocarboxylic acid metabolic process |
| positive regulation of protein kinase activity |
| organophosphate biosynthetic process |
| positive regulation of MAPK cascade |
| chemotaxis |
| taxis |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| actin filament-based process |
| positive regulation of kinase activity |
| lipid biosynthetic process |
| anion transport |
| small molecule biosynthetic process |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cell surface |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| response to bacterium |
| regulation of ion transport |
| cation homeostasis |
| regulation of protein transport |
| inorganic ion homeostasis |
| calcium ion binding |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| leukocyte mediated immunity |
| innate immune response |
| positive regulation of hydrolase activity |
| ion homeostasis |
| regulation of protein kinase activity |
| regulation of secretion |
| positive regulation of immune response |
| regulation of kinase activity |
| organophosphate metabolic process |
| cellular homeostasis |
| response to hormone |
| carboxylic acid metabolic process |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| defense response to other organism |
| cellular lipid metabolic process |
| cell migration |
| regulation of transferase activity |
| positive regulation of transport |
| response to organonitrogen compound |
| oxoacid metabolic process |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| organic acid metabolic process |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| localization of cell |
| cell motility |
| response to nitrogen compound |
| immune effector process |
| cytoskeleton organization |
| chemical homeostasis |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| lipid metabolic process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| defense response |
| ion transport |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| small molecule metabolic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| SNS-032 15μM R08 exp443 | -2.07 |
| Thalidomide 20μM R07 exp406 | -1.99 |
| Ethambutol 25μM R08 exp481 | 1.72 |
| Rifampicin 10μM R00 exp32 | 1.86 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14443
- Expression level (log2 read counts): -5.6
Expression Distribution
PLA2G1B Expression in NALM6 Cells: -5.6
