PAPSS1

Gene Information

Official Symbol: PAPSS1
Official Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Aliases and Previous Symbols: N/A
Entrez ID: 9061
UniProt: O43252
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway (PubMed:9576487, PubMed:9668121, PubMed:9648242, PubMed:14747722). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487). {ECO:0000269|PubMed:14747722, ECO:0000269|PubMed:9576487, ECO:0000269|PubMed:9648242, ECO:0000269|PubMed:9668121}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CI-1040 9.5μM R08 exp472	-2.08
Hydroxyurea 100μM R07 exp329	-1.87
SB203580 25μM R03 exp149	2.04
Thalidomide 20μM R07 exp406	2.19
VER-155008 3.9μM R06 exp301	2.38
Pyridostatin 4μM R05 exp240	2.94

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5264
Expression level (log2 read counts): 5.12

Expression Distribution

Gene	Correlation
UGDH	0.45
FAM20B	0.447
B3GAT3	0.426

ATP-sulfurylase
APS kinase

adenylylsulfate kinase activity
sulfate adenylyltransferase (ATP) activity
sulfate assimilation
purine ribonucleoside bisphosphate biosynthetic process
3-phosphoadenosine 5-phosphosulfate biosynthetic process
nucleotidyltransferase activity
3-phosphoadenosine 5-phosphosulfate metabolic process
purine ribonucleoside bisphosphate metabolic process
ribonucleoside bisphosphate biosynthetic process
nucleoside bisphosphate biosynthetic process
purine nucleoside bisphosphate biosynthetic process
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
sulfur compound biosynthetic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
sulfur compound metabolic process
purine-containing compound metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
skeletal system development
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
protein homodimerization activity
organophosphate metabolic process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
nucleobase-containing compound biosynthetic process