UGDH

Entrez Summary: N/A
UniProt Summary: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
HGC6.3	0.571
PAPSS1	0.45

UDP-glucose 6-dehydrogenase activity
UDP-glucuronate biosynthetic process
UDP-glucuronate metabolic process
protein hexamerization
nucleotide-sugar biosynthetic process
chondroitin sulfate biosynthetic process
gastrulation with mouth forming second
heparan sulfate proteoglycan biosynthetic process
chondroitin sulfate proteoglycan biosynthetic process
heparan sulfate proteoglycan metabolic process
nucleotide-sugar metabolic process
chondroitin sulfate metabolic process
NAD binding
chondroitin sulfate proteoglycan metabolic process
proteoglycan biosynthetic process
proteoglycan metabolic process
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
glycosaminoglycan metabolic process
gastrulation
aminoglycan metabolic process
sulfur compound biosynthetic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
glycoprotein biosynthetic process
sulfur compound metabolic process
glycoprotein metabolic process
carbohydrate metabolic process
protein complex oligomerization
nucleobase-containing small molecule metabolic process
embryonic morphogenesis
small molecule biosynthetic process
carbohydrate derivative biosynthetic process
carboxylic acid metabolic process
oxidation-reduction process
embryo development
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process