G0S2

Entrez Summary: N/A
UniProt Summary: Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. {ECO:0000269|PubMed:19706769}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of extrinsic apoptotic signaling pathway
lipid droplet
extrinsic apoptotic signaling pathway
positive regulation of cold-induced thermogenesis
regulation of cold-induced thermogenesis
regulation of extrinsic apoptotic signaling pathway
positive regulation of apoptotic signaling pathway
apoptotic signaling pathway
regulation of lipid metabolic process
regulation of apoptotic signaling pathway
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
molecular function
apoptotic process
programmed cell death
cell death
mitochondrion
regulation of apoptotic process
regulation of programmed cell death
positive regulation of signal transduction
regulation of cell death
positive regulation of multicellular organismal process
positive regulation of cell communication
positive regulation of signaling