MAPK11
Gene Information
- Official Symbol: MAPK11
- Official Name: mitogen-activated protein kinase 11
- Aliases and Previous Symbols: N/A
- Entrez ID: 5600
- UniProt: Q15759
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Kdo |
| Pkinase |
| Pkinase Tyr |
GO Terms
| positive regulation of interleukin-12 secretion |
| regulation of interleukin-12 secretion |
| negative regulation of cardiac muscle cell proliferation |
| MAP kinase activity |
| negative regulation of cardiac muscle tissue growth |
| negative regulation of heart growth |
| positive regulation of erythrocyte differentiation |
| negative regulation of organ growth |
| negative regulation of cardiac muscle tissue development |
| cellular response to virus |
| positive regulation of interleukin-12 production |
| regulation of cardiac muscle cell proliferation |
| regulation of erythrocyte differentiation |
| negative regulation of striated muscle tissue development |
| negative regulation of muscle organ development |
| negative regulation of muscle tissue development |
| regulation of interleukin-12 production |
| regulation of cardiac muscle tissue growth |
| regulation of heart growth |
| vascular endothelial growth factor receptor signaling pathway |
| regulation of cardiac muscle tissue development |
| positive regulation of muscle cell differentiation |
| positive regulation of myeloid cell differentiation |
| regulation of organ growth |
| negative regulation of developmental growth |
| stress-activated MAPK cascade |
| regulation of striated muscle tissue development |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| positive regulation of cytokine secretion |
| stress-activated protein kinase signaling cascade |
| regulation of muscle cell differentiation |
| activation of MAPK activity |
| cellular response to interleukin-1 |
| regulation of signal transduction by p53 class mediator |
| positive regulation of hemopoiesis |
| response to interleukin-1 |
| regulation of cytokine secretion |
| regulation of myeloid cell differentiation |
| negative regulation of growth |
| Ras protein signal transduction |
| positive regulation of MAP kinase activity |
| positive regulation of protein secretion |
| response to virus |
| positive regulation of peptide secretion |
| small GTPase mediated signal transduction |
| activation of protein kinase activity |
| regulation of developmental growth |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| protein serine/threonine kinase activity |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| positive regulation of secretion by cell |
| positive regulation of protein transport |
| regulation of DNA-binding transcription factor activity |
| positive regulation of secretion |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of peptide secretion |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| regulation of growth |
| negative regulation of cell population proliferation |
| regulation of cytokine production |
| regulation of protein transport |
| enzyme linked receptor protein signaling pathway |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| regulation of secretion |
| regulation of kinase activity |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| protein phosphorylation |
| regulation of transferase activity |
| positive regulation of transport |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| positive regulation of phosphorylation |
| response to cytokine |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| phosphorylation |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| ATP binding |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of signal transduction |
| regulation of immune system process |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16814
- Expression level (log2 read counts): 0.84
Expression Distribution
MAPK11 Expression in NALM6 Cells: 0.84
