FZR1

Gene Information

Official Symbol: FZR1
Official Name: fizzy and cell division cycle 20 related 1
Aliases and Previous Symbols: N/A
Entrez ID: 51343
UniProt: Q9UM11
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Etoposide 0.1μM R05 exp198	-3.52
Hippuristanol 0.12μM R08 exp488	-2.98
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.87
MK-1775 0.32μM R02 exp75	-2.74
LY2090314 0.003μM R08 exp499	-2.49
MLN-4924 0.2μM R00 exp21	-2.45
LB-100 2μM R05 exp210	-2.41
Rapamycin 2μM R07 exp306	-2.37
GSK626616 14μM R08 exp485	-2.32
Pyridostatin 4μM R05 exp240	-2.06
HMS-I2 10μM R06 exp288	-2.05
Thalidomide 20μM R07 exp406	-2.03
Lapatinib 5μM R01 exp47	-2.02
Pimelic-diphenylamide-106 0.5μM R00 exp27	-1.92
Genistein 15μM R07 exp360	-1.91
ETC-159 50μM R08 exp480	-1.89
VE-822 0.04μM R06 exp300	-1.85
Campthothecin 0.001μM R06 exp270	-1.82
Deguelin 0.15μM R05 exp209	-1.82
LY2090314 0.003μM R08 exp500 no dilution day6	-1.82
Citral 50μM R06 exp274	-1.81
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.79
Fas-L 44ng/ml R08 exp482	-1.79
NFN1 0.4μM R03 exp99	-1.78
Nifuroxazide 5μM R03 exp102	-1.77
Rapamycin 1μM R00 exp29	-1.77
Wortmannin 5μM R00 exp38	-1.76
Rapamycin 10μM R00 exp30	-1.72
B02 10μM R08 exp453	-1.71
WNT3A 44ng/ml R08 exp537	-1.7
Betulinic acid 10 to 15μM on day4 R05 exp222	1.72

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3629
Expression level (log2 read counts): 5.84

Expression Distribution

anaphase-promoting complex binding
ubiquitin-protein transferase activator activity
positive regulation of ubiquitin protein ligase activity
signal transduction involved in G2 DNA damage checkpoint
anaphase-promoting complex
regulation of ubiquitin protein ligase activity
negative regulation of cell aging
lens fiber cell differentiation
G2 DNA damage checkpoint
protein K11-linked ubiquitination
regulation of meiotic nuclear division
positive regulation of ubiquitin-protein transferase activity
regulation of cell aging
regulation of meiotic cell cycle
regulation of ubiquitin-protein transferase activity
signal transduction involved in DNA integrity checkpoint
signal transduction involved in DNA damage checkpoint
signal transduction involved in cell cycle checkpoint
lens development in camera-type eye
anaphase-promoting complex-dependent catabolic process
negative regulation of cell cycle G2/M phase transition
signal transduction in response to DNA damage
positive regulation of protein ubiquitination
DNA damage checkpoint
positive regulation of protein modification by small protein conjugation or removal
DNA integrity checkpoint
regulation of reproductive process
regulation of nuclear division
cell cycle checkpoint
regulation of protein ubiquitination
regulation of cell cycle G2/M phase transition
positive regulation of protein catabolic process
regulation of protein modification by small protein conjugation or removal
negative regulation of cell cycle phase transition
nuclear membrane
protein polyubiquitination
camera-type eye development
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of cell cycle process
proteasomal protein catabolic process