FZR1 [The Human Chemical-Genetic Interaction Map Project]

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======= FZR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FZR1
  * **<color #00a2e8>Official Name</color>**: fizzy and cell division cycle 20 related 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51343|51343]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UM11|Q9UM11]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FZR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FZR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603619|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|anaphase-promoting complex binding|
|ubiquitin-protein transferase activator activity|
|positive regulation of ubiquitin protein ligase activity|
|signal transduction involved in G2 DNA damage checkpoint|
|anaphase-promoting complex|
|regulation of ubiquitin protein ligase activity|
|negative regulation of cell aging|
|lens fiber cell differentiation|
|G2 DNA damage checkpoint|
|protein K11-linked ubiquitination|
|regulation of meiotic nuclear division|
|positive regulation of ubiquitin-protein transferase activity|
|regulation of cell aging|
|regulation of meiotic cell cycle|
|regulation of ubiquitin-protein transferase activity|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in cell cycle checkpoint|
|lens development in camera-type eye|
|anaphase-promoting complex-dependent catabolic process|
|negative regulation of cell cycle G2/M phase transition|
|signal transduction in response to DNA damage|
|positive regulation of protein ubiquitination|
|DNA damage checkpoint|
|positive regulation of protein modification by small protein conjugation or removal|
|DNA integrity checkpoint|
|regulation of reproductive process|
|regulation of nuclear division|
|cell cycle checkpoint|
|regulation of protein ubiquitination|
|regulation of cell cycle G2/M phase transition|
|positive regulation of protein catabolic process|
|regulation of protein modification by small protein conjugation or removal|
|negative regulation of cell cycle phase transition|
|nuclear membrane|
|protein polyubiquitination|
|camera-type eye development|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|proteasomal protein catabolic process|
|eye development|
|visual system development|
|sensory system development|
|regulation of protein catabolic process|
|regulation of mitotic cell cycle phase transition|
|positive regulation of catabolic process|
|regulation of cell cycle phase transition|
|cell division|
|DNA repair|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|sensory organ development|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|epithelial cell differentiation|
|protein catabolic process|
|protein ubiquitination|
|DNA metabolic process|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|cellular macromolecule catabolic process|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|epithelium development|
|regulation of cell cycle|
|positive regulation of protein modification process|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|positive regulation of catalytic activity|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|tissue development|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-3.52|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.98|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.87|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.74|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.49|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.45|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.41|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.37|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.32|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-2.06|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-2.05|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-2.03|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.02|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.92|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.91|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.89|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-1.85|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.82|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.82|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.82|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.81|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.79|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-1.79|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.78|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.77|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.77|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.76|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.72|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.71|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.7|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3629
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FZR1 Expression in NALM6 Cells: 5.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>