CNNM4

Official Symbol: CNNM4
Official Name: cyclin and CBS domain divalent metal cation transport mediator 4
Aliases and Previous Symbols: N/A
Entrez ID: 26504
UniProt: Q6P4Q7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play a role in metal ion transport. Mutations in this gene are associated with Jalili syndrome which consists of cone-rod dystrophy and amelogenesis imperfecta. [provided by RefSeq, Feb 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sodium ion transmembrane transporter activity
magnesium ion homeostasis
enamel mineralization
tooth mineralization
magnesium ion transmembrane transporter activity
magnesium ion transmembrane transport
magnesium ion transport
amelogenesis
transmembrane transporter activity
odontogenesis of dentin-containing tooth
sodium ion transmembrane transport
biomineral tissue development
biomineralization
odontogenesis
sodium ion transport
basolateral plasma membrane
visual perception
sensory perception of light stimulus
divalent metal ion transport
divalent inorganic cation transport
neuronal cell body
monovalent inorganic cation transport
dendrite
divalent inorganic cation homeostasis
inorganic cation transmembrane transport
protein-containing complex
cation transmembrane transport
metal ion homeostasis
metal ion transport
inorganic ion transmembrane transport
cation homeostasis
inorganic ion homeostasis
ion homeostasis
cation transport
anatomical structure formation involved in morphogenesis
ion transmembrane transport
animal organ morphogenesis
sensory perception
chemical homeostasis
transmembrane transport