SGTA

Gene Information

Official Symbol: SGTA
Official Name: small glutamine rich tetratricopeptide repeat containing alpha
Aliases and Previous Symbols: N/A
Entrez ID: 6449
UniProt: O43765
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Probably functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457). {ECO:0000269|PubMed:18759457, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8802
Expression level (log2 read counts): 6.61

Expression Distribution

Screen	Score
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	1.79
GSK-J4 1-1.25μM to day4 R07 exp363	1.94
Salubrinal 20μM R07 exp399	2.79

TPR 1
TPR 2

TRC complex
positive regulation of chaperone-mediated protein folding
positive regulation of protein folding
negative regulation of ER-associated ubiquitin-dependent protein catabolic process
regulation of chaperone-mediated protein folding
extrinsic component of synaptic vesicle membrane
BAT3 complex binding
tail-anchored membrane protein insertion into ER membrane
protein insertion into ER membrane
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
regulation of ER-associated ubiquitin-dependent protein catabolic process
regulation of protein folding
posttranslational protein targeting to endoplasmic reticulum membrane
negative regulation of ERAD pathway
positive regulation of ERAD pathway
regulation of ERAD pathway
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
protein insertion into membrane
positive regulation of response to endoplasmic reticulum stress
negative regulation of response to endoplasmic reticulum stress
negative regulation of ubiquitin-dependent protein catabolic process
endoplasmic reticulum organization
protein self-association
negative regulation of proteasomal protein catabolic process
chaperone-mediated protein folding
ubiquitin-dependent ERAD pathway
negative regulation of proteolysis involved in cellular protein catabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of response to endoplasmic reticulum stress
negative regulation of cellular protein catabolic process
ERAD pathway
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of protein catabolic process
protein localization to endoplasmic reticulum
positive regulation of cellular protein catabolic process