ANKRD2

Gene Information

Official Symbol: ANKRD2
Official Name: ankyrin repeat domain 2
Aliases and Previous Symbols: N/A
Entrez ID: 26287
UniProt: Q9GZV1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein that belongs to the muscle ankyrin repeat protein (MARP) family. A similar gene in rodents is a component of a muscle stress response pathway and plays a role in the stretch-response associated with slow muscle function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014].
UniProt Summary: Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. {ECO:0000269|PubMed:21737686, ECO:0000269|PubMed:22016770}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13703
Expression level (log2 read counts): -6.6

Expression Distribution

Screen	Score
YM155 0.001μM R08 exp432	-1.94
TNF-alpha 44ng/ml R08 exp533	-1.7
A-395 10μM R05 exp218	1.8

Ank
Ank 2

RNA polymerase II-specific DNA-binding transcription factor binding
euchromatin
protein kinase B binding
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
regulation of myoblast proliferation
titin binding
negative regulation of myotube differentiation
I band
negative regulation of myoblast differentiation
regulation of intrinsic apoptotic signaling pathway by p53 class mediator
negative regulation of striated muscle cell differentiation
structural constituent of muscle
skeletal muscle cell differentiation
regulation of myoblast differentiation
negative regulation of muscle cell differentiation
regulation of myotube differentiation
PML body
regulation of striated muscle cell differentiation
regulation of transcription from RNA polymerase II promoter in response to stress
skeletal muscle tissue development
regulation of DNA-templated transcription in response to stress
skeletal muscle organ development
regulation of muscle cell differentiation
regulation of intrinsic apoptotic signaling pathway
regulation of signal transduction by p53 class mediator
cellular response to oxidative stress
muscle contraction
striated muscle tissue development
muscle organ development
muscle tissue development
muscle system process
response to oxidative stress
chromatin binding
regulation of apoptotic signaling pathway
muscle structure development
intracellular membrane-bounded organelle
regulation of cytokine production
negative regulation of cell differentiation
negative regulation of transcription by RNA polymerase II
negative regulation of developmental process