TCF7L2
Gene Information
- Official Symbol: TCF7L2
- Official Name: transcription factor 7 like 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 6934
- UniProt: Q9NQB0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| CTNNB1 binding |
| HMG box |
GO Terms
| canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition |
| regulation of heparan sulfate proteoglycan biosynthetic process |
| beta-catenin-TCF7L2 complex |
| positive regulation of proteoglycan biosynthetic process |
| positive regulation of heparan sulfate proteoglycan biosynthetic process |
| myoblast fate commitment |
| negative regulation of type B pancreatic cell apoptotic process |
| maintenance of DNA repeat elements |
| regulation of type B pancreatic cell apoptotic process |
| armadillo repeat domain binding |
| gamma-catenin binding |
| positive regulation of glycoprotein biosynthetic process |
| positive regulation of protein export from nucleus |
| positive regulation of glycoprotein metabolic process |
| nuclear hormone receptor binding |
| beta-catenin-TCF complex assembly |
| RNA polymerase II repressing transcription factor binding |
| myoblast differentiation |
| Wnt signaling pathway, calcium modulating pathway |
| regulation of protein export from nucleus |
| regulation of hormone metabolic process |
| regulation of glycoprotein biosynthetic process |
| negative regulation of epithelial cell apoptotic process |
| protein-DNA complex |
| regulation of glycoprotein metabolic process |
| positive regulation of epithelial to mesenchymal transition |
| positive regulation of nucleocytoplasmic transport |
| positive regulation of insulin secretion |
| pancreas development |
| regulation of epithelial cell apoptotic process |
| beta-catenin binding |
| regulation of epithelial to mesenchymal transition |
| canonical Wnt signaling pathway |
| positive regulation of protein binding |
| positive regulation of peptide hormone secretion |
| PML body |
| negative regulation of extrinsic apoptotic signaling pathway |
| fat cell differentiation |
| regulation of nucleocytoplasmic transport |
| positive regulation of hormone secretion |
| regulation of smooth muscle cell proliferation |
| non-canonical Wnt signaling pathway |
| response to glucose |
| response to hexose |
| cell cycle arrest |
| response to monosaccharide |
| positive regulation of intracellular protein transport |
| regulation of extrinsic apoptotic signaling pathway |
| negative regulation of DNA-binding transcription factor activity |
| positive regulation of protein kinase B signaling |
| response to carbohydrate |
| negative regulation of canonical Wnt signaling pathway |
| positive regulation of binding |
| regulation of insulin secretion |
| glucose homeostasis |
| carbohydrate homeostasis |
| positive regulation of epithelial cell proliferation |
| transcription factor complex |
| positive regulation of intracellular transport |
| regulation of peptide hormone secretion |
| negative regulation of Wnt signaling pathway |
| transcription regulatory region DNA binding |
| regulation of protein binding |
| regulation of protein kinase B signaling |
| negative regulation of apoptotic signaling pathway |
| regulation of intracellular protein transport |
| nuclear chromatin |
| cell fate commitment |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| regulation of canonical Wnt signaling pathway |
| positive regulation of peptide secretion |
| positive regulation of cellular protein localization |
| transcription factor binding |
| regulation of epithelial cell proliferation |
| regulation of intracellular transport |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| regulation of Wnt signaling pathway |
| regulation of binding |
| chromatin binding |
| regulation of apoptotic signaling pathway |
| positive regulation of secretion by cell |
| sequence-specific DNA binding |
| positive regulation of protein transport |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of DNA-binding transcription factor activity |
| positive regulation of secretion |
| positive regulation of establishment of protein localization |
| protein kinase binding |
| regulation of protein secretion |
| muscle structure development |
| blood vessel development |
| regulation of peptide secretion |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| vasculature development |
| cardiovascular system development |
| regulation of hormone levels |
| regulation of cellular protein localization |
| negative regulation of cell cycle |
| DNA-binding transcription factor activity |
| regulation of protein transport |
| regulation of peptide transport |
| DNA metabolic process |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of secretion |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| positive regulation of cell differentiation |
| positive regulation of transport |
| negative regulation of cell death |
| cell cycle process |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| chromosome organization |
| chemical homeostasis |
| cell-cell signaling |
| negative regulation of molecular function |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| negative regulation of RNA metabolic process |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| protein-containing complex subunit organization |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.514 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 6/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 2/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 1/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7988
- Expression level (log2 read counts): 3.45
Expression Distribution
TCF7L2 Expression in NALM6 Cells: 3.45
